Size-adjustable ring-shape photoacoustic tomography imager in vivo

Daohuai Jiang1,2,3, Yifei Xu1, Hengrong Lan1,2,3, Yuting Shen1, Yifan Zhang1,Feng Gao1, Li Liu4*,  Fei Gao1,5*

 

Affiliations

1: Hybrid Imaging System Laboratory, School of Information Science and Technology, ShanghaiTech University, Shanghai, China
2: Chinese Academy of Sciences, Shanghai Institute of Microsystem and Information Technology, Shanghai, China
3: University of Chinese Academy of Sciences, Beijing, China
4: Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong, China
5: Shanghai Engineering Research Center of Energy Efficient and Custom AI IC, Shanghai, China

*Correspondence
Fei Gao, Hybrid Imaging System Laboratory (HISLab), Shanghai Engineering Research Center of Energy Efficient and Custom AI IC, School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Email: gaofei@shanghaitech.edu.cn

Li Liu, Department of Electronic Engineering, the Chinese University of Hong Kong, Hong Kong, China.
Email: liliu@cuhk.edu.hk

Abstract

Photoacoustic tomography (PAT) has become a novel biomedical imaging modality for scientific research and clinical
diagnosis. It combines the advantages of spectroscopic optical absorption contrast and acoustic resolution with deep penetration. In this article, an imaging size-adjustable PAT system is proposed for potential clinical applications such as breast cancer detection and screening, which can adapt to imaging targets with various sizes. Comparing with the conventional PAT setup with a fixed radius ring shape ultrasound transducer (UT) array, the proposed system is more flexible for imaging diverse size targets based on sectorial ultrasound transducer arrays (SUTAs). Four SUTAs form a 128-channel UT array for photoacoustic detection, where each SUTA has 32 elements. Such four SUTAs are controlled by four stepper motors, respectively, and can change their distribution layout position to adapt for various imaging applications. In this proposed system, the radius of the imaging region of interest (ROI) can be adjusted from 50 to 100 mm, which is much more flexible than the conventional PAT system with a full ring UT array. The simulation experiments using the MATLAB k-wave toolbox demonstrate the feasibility of the proposed system. To further validate the proposed system, imaging of pencil leads made phantom, ex-vivo pork breast with indocyanine green (ICG) injected, and in-vivo human wrist, finger and ankle are conducted to prove its feasibility for potential clinical applications

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