Author(s): Shangqing Tong, Peng Ge, Yanan Jiao, Zhaofu Ma, Ziye Li, Longhai Liu, Feng Gao, Xiaohui Du, Fei Gao ABSTRACT Colorectal cancer is a deadly disease that has become increasingly prevalent in recent years. Early detection is crucial for saving lives, but traditional diagnostic methods such as colonoscopy and biopsy have limitations. Colonoscopy cannot provide detailed information within the tissues affected by cancer, […]
Tag: Cancer Imaging
Clinical Pilot Study of Ionizing Radiation Acoustic Imaging for Real-Time Visualization of Radiation Therapy Dose Delivery in Cancer Patients
Author(s): K. C. Cuneo, W. Zhang, D. Litzenberg, Y. Huang, S. Hadley, I. Oraiqat, K.-W. Chang, G. Gonzalez, S. Dykstra, M. Zhang, E. G. Moros, P. L. Carson, I. El Naqa, and X. Wang ABSTRACT This study aimed to evaluate the feasibility of using ionizing radiation acoustic imaging (iRAI) to map the delivered dose in […]
Water-Soluble Fe(II) Complexes for Theranostic Application: Synthesis, Photoacoustic Imaging, and Photothermal Conversion
Authors: Maeva Delcroix, Dr. Anil Reddy Marri, Stéphane Parant, Dr. Philippe C. Gros, Dr. Mathilde Bouché ABSTRACT Significant effort focused on developing photoactivatable theranostics for localized image guided therapy of cancer by thermal ablation. In this context iron complexes were recently identified as photoactivatable theranostic agents with adequate biocompatibility and body clearance. Herein, a series of FeII complexes bearing polypyridine […]
NON-INVASIVE 3D PHOTOACOUSTIC TOMOGRAPHY OF ANGIOGRAPHIC ANATOMY AND HEMODYNAMICS OF FATTY LIVERS IN RATS
Author(s): Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson,and Lihong V. Wang ABSTRACT Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional optical contrast. However, […]
WHOLE-BODY HUMAN ULTRASOUND TOMOGRAPHY
Author(s): D. C. Garrett, J. Xu, D. Oh, Y. Aborahama, G. Ku, K. Maslov, W. W. Tseng, and L. V. Wang ABSTRACT We developed a system for whole-body human ultrasound tomography in reflection andtransmission modes. A custom 512-element ultrasound receiver array with a rotating single-element ultrasound transmitter are used to generate 2D isotropically resolved images […]
CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN
Authors: Diego S. Dumani, Hans-Peter Brecht, Vassili Ivanov, Ryan Deschner, Justin T. Harris, Kimberly A. Homan, Jason R. Cook, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition […]
DUAL-MODALITY X-RAY-INDUCED RADIATION ACOUSTIC AND ULTRASOUND IMAGING FOR REAL-TIME MONITORING OF RADIOTHERAPY
Authors: Wei Zhang,1 Ibrahim Oraiqat,2 Hao Lei,3 Paul L. Carson,1,4 Issam EI Naqa,2 and Xueding Wang1,4 ABSTRACT Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) […]
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kim, Anthony M Yu, Kelsey P. Kubelick, Stanislav Y. Emelianov Fig. 5. Spectroscopic analysis and PAT of the MMP sensor in an in vivo mouse model of breast cancer. (a) PA intensity from 680 nm to 970 nm of the MMP sensor in the tumor region and assorted controls – saline only and control sensor. Black dashed line […]
SIZE-ADJUSTABLE RING-SHAPE PHOTOACOUSTIC TOMOGRAPHY IMAGER IN VIVO
Author(s): Daohuai Jiang1,2,3, Yifei Xu1, Hengrong Lan1,2,3, Yuting Shen1, Yifan Zhang1,Feng Gao1, Li Liu4*, Fei Gao1,5* ABSTRACT Photoacoustic tomography (PAT) has become a novel biomedical imaging modality for scientific research and clinical diagnosis. It combines the advantages of spectroscopic optical absorption contrast and acoustic resolution with deep penetration. In this article, an imaging size-adjustable PAT […]
REAL-TIME, VOLUMETRIC IMAGING OF RADIATION DOSE DELIVERY DEEP INTO THE LIVER DURING CANCER TREATMENT
Authors: Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Ba Sunbul, Martha M. Matuszak, Christopher J. Tichacek, Eduardo G. Moros, Paul L. Carson, Kyle C. Cuneo, Xueding Wang, & Issam El Naqa ABSTRACT Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive […]
