Authors: Weylan Thompson, Anthony Yu, Diego S. Dumani, Jason Cook, Mark A. Anastasio, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]
Tag: 3D
PHOTOACOUSTIC IMAGE-GUIDED DELIVERY OF PLASMONIC-NANOPARTICLE-LABELED MESENCHYMAL STEM CELLS TO THE SPINAL CORD
Authors: Eleanor M. Donnelly, Kelsey P. Kubelick, Diego S. Dumani, and Stanislav Y. Emelianov ABSTRACT Regenerative therapies using stem cells have great potential for treating neurodegenerative diseases and traumatic injuries in the spinal cord. In spite of significant research efforts, many therapies fail at the clinical phase. As stem cell technologies advance toward clinical use, […]
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
NON-INVASIVE PHOTOACOUSTIC COMPUTED TOMOGRAPHY OF RAT HEART ANATOMY AND FUNCTION
Author(s): Li Lin, Xin Tong, Susana Cavallero, Yide Zhang, Shuai Na, Rui Cao, Tzung K. Hsiai, and Lihong V. Wang ABSTRACT Photoacoustic computed tomography (PACT) combines optical contrast with acoustic-resolution imaging, but non-invasive cardiac imaging with this technique has been limited by signal loss and distortion caused by the chest wall. This work presents a […]
AUTOMATIC FORCE-CONTROLLED 3D PHOTOACOUSTIC SYSTEM FOR HUMAN PERIPHERAL VASCULAR IMAGING
Author(s): David C. Garrett, Jinhua Xu, Geng Ku, and Lihong V. Wang Fig. 1. The composition of the system. (A) The system schematics. (B) The photograph of the experiment. PA: photoacoustic; US: ultrasound ABSTRACT We developed a system for whole-body human ultrasound tomography in reflection and transmission modes. A custom 512-element ultrasound receiver array with a […]
HIGH-SPEED THREE-DIMENSIONAL PHOTOACOUSTIC COMPUTED TOMOGRAPHY FOR PRECLINICAL RESEARCH AND CLINICAL TRANSLATION
Authors: Li Lin, Peng Hu, Xin Tong, Rui Cao, Xiaoyun Yuan, David C. Garrett, Junhui Shi, Konstantin Maslov & Lihong V. Wang ABSTRACT Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential […]
