What is Multimodal Imaging? Multimodal Imaging is the combination of two or more imaging modalities that leverage the strengths of each modality. Multimodal imaging enhances the anatomical, functional, and molecular information obtained in a single imaging session. PhotoSound’s Tritom imaging system utilizes the same short pulse duration OPO light source to generate the photoacoustic as […]
Tag: 3D
Neuroimaging
What is Neuroimaging? Neuroimaging is the use of medical imaging techniques to study the structure and function of the nervous system, focusing on the brain. Photoacoustic tomography has been used to image the brain, spinal cord, and other parts of the nervous system. PhotoSound Product Used TriTom Monitoring Neonatal Brain Hemorrhage Progression by Photoacoustic Tomography […]
Anatomical Imaging
What is anatomical imaging? Anatomical imaging is used to visualize the structure and organization of tissues and organs within the body. Photoacoustic tomography generates high-resolution images of blood-rich tissues without the need for exogenous contrast agents. PhotoSound Product Used TriTom Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot Photoacoustic tomography to assess […]
CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN
Authors: Diego S. Dumani1,2, Hans-Peter Brecht3, Vassili Ivanov3, Ryan Deschner4, Justin T. Harris4, Kimberly A. Homan4, Jason R. Cook5, Stanislav Y. Emelianov1,2, Sergey A. Ermilov3 ABSTRACT We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition […]
A PRECLINICAL SMALL ANIMAL IMAGING PLATFORM COMBINING MULTI-ANGLE PHOTOACOUSTIC AND FLUORESCENCE PROJECTIONS INTO CO-REGISTERED 3D MAPS
Authors: Weylan Thompson1, Anthony Yu2,3, Diego S. Dumani2,3,4, Jason Cook5, Mark A. Anastasio6, Stanislav Y. Emelianov2,3, Sergey A. Ermilov1 ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]
PHOTOACOUSTIC IMAGE-GUIDED DELIVERY OF PLASMONIC-NANOPARTICLE-LABELED MESENCHYMAL STEM CELLS TO THE SPINAL CORD
Authors: Eleanor M. Donnelly1, Kelsey P. Kubelick2, Diego S. Dumani1,2, and Stanislav Y. Emelianov1,2 ABSTRACT Regenerative therapies using stem cells have great potential for treating neurodegenerative diseases and traumatic injuries in the spinal cord. In spite of significant research efforts, many therapies fail at the clinical phase. As stem cell technologies advance toward clinical use, […]
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
NON-INVASIVE PHOTOACOUSTIC COMPUTED TOMOGRAPHY OF RAT HEART ANATOMY AND FUNCTION
Author(s): Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson, Lihong V. Wang ABSTRACT Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional optical contrast. However, PAT has not been demonstrated to […]
AUTOMATIC FORCE-CONTROLLED 3D PHOTOACOUSTIC SYSTEM FOR HUMAN PERIPHERAL VASCULAR IMAGING
Author(s): David C. Garrett, Jinhua Xu, Geng Ku, and Lihong V. Wang ABSTRACT We developed a system for whole-body human ultrasound tomography in reflection and transmission modes. A custom 512-element ultrasound receiver array with a rotating single-element ultrasound transmitter are used to generate 2D isotropically resolved images across the entire human cross-section. We demonstrate this […]
HIGH-SPEED THREE-DIMENSIONAL PHOTOACOUSTIC COMPUTED TOMOGRAPHY FOR PRECLINICAL RESEARCH AND CLINICAL TRANSLATION
Authors: Li Lin1,4, Peng Hu1,4, Xin Tong1,4, Rui Cao1, Xiaoyun Yuan1,2, David C. Garrett1, Junhui Shi1,3, Konstantin Maslov1 & Lihong V. Wang1 ABSTRACT Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications […]