Author(s): Zhenxiang Zhao, Chelsea Swartchick, Jefferson Chan ABSTRACT Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution visualization of biological processes within deep tissue. Through the development and application of exogenous targeted contrast agents and activatable probes that can respond to a given cancer biomarker, researchers can image molecular events in vivo during cancer progression. […]
Tag: contrast agents
Bornite (Cu5FeS4) nanocrystals as an ultrasmall biocompatible NIR-II contrast agent for photoacoustic imaging
Author(s):Vinoin Devpaul Vincely, Xingjian Zhong, Kristie Huda, Swathi P. Katakam, Joshua C. Kays, Allison M. Dennis, Carolyn L. Bayer ABSTRACT In this study, we demonstrate the potential of the bornite crystal structure (Cu5FeS4) of copper iron sulfide as a second near infrared (NIR-II) photoacoustic (PA) contrast agent. Bornite exhibits comparable dose-dependent biocompatibility to copper sulfide nanoparticles in a cell viability study with HepG2 cells, while exhibiting a 10-fold increase […]
Phototherapy mode control by tuning molecular and supramolecular forms of indocyanine green in crosslinked polyion complex nanoparticles
Author(s): Aixa Aguilera-Garrido, Marie Millard, Mathilde Bouché, Pascal Lemière, Nadia Canilho, Andreea Pasc, Kazunori Kataoka, Joachim F.R. Van Guyse, Henri-Pierre Lassalle, Yann Bernhard ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for treating hypoxic tumors, while photodynamic therapy (PDT) is limited by its oxygen dependence. Indocyanine green (ICG) is a clinically approved near-infrared (NIR) […]
A comparative study of plasmonic nanoparticles for targeted photothermal therapy of melanoma tumors using various irradiation modes
Author(s): L. Mikhailova, E. Vysotina, M. Timofeeva, E. Kopoleva, V. Gulinyan, O. Pashina, K. Arabuli, O. Gusliakova, E. Prikhozhdenko, X. Qi, A. Petrov, E. Ageev, M. Petrov, C. De Angelis, M. Durymanov, G. Sukhorukov, and M. V. Zyuzin ABSTRACT Melanoma, a highly malignant and complex form of cancer, has increased in global incidence, with a […]
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kim, Anthony M Yu, Kelsey P. Kubelick, Stanislav Y. Emelianov Fig. 5. Spectroscopic analysis and PAT of the MMP sensor in an in vivo mouse model of breast cancer. (a) PA intensity from 680 nm to 970 nm of the MMP sensor in the tumor region and assorted controls – saline only and control sensor. Black dashed line […]
IN SITU X-RAY-INDUCED ACOUSTIC COMPUTED TOMOGRAPHY WITH A CONTRAST AGENT: A PROOF OF CONCEPT
Authors: Seongwook Choi,1; Sinyoung Park,1; Ayoung Pyo,2; Dong-Yeon Kim,3 ; Jung-Joon Min,4 ; Changho Lee,4,5,6; Chulhong Kim,1,7 ABSTRACT X-ray-induced acoustic computed tomography (XACT) has shown great potential as a hybrid imaging modality for real-time non-invasive x-ray dosimetry and low-dose three- dimensional (3D) imaging. While promising, one drawback of the XACT system is the underlying low signal-to-noise ratio […]
BIODEGRADABLE AND BIOCOMPATIBLE SEMICONDUCTOR NANOCRYSTALS AS NIR-II PHOTOACOUSTIC IMAGING CONTRAST AGENTS
Author(s): Vinoin Devpaul Vincely, Swathi P. Katakam, Kristie Huda, Xingjian Zhong, Joshua C. Kays, Allison M. Dennis, Carolyn L. Bayer ABSTRACT Transabdominal imaging using photoacoustics (PA) is limited by optical attenuation of tissue due to high scattering and absorption in the near infrared (NIR) window. Tissue attenuation is lowered when imaging with longer wavelengths in the NIR window (> 950 nm). […]
