What is anatomical imaging? Anatomical imaging is used to visualize the structure and organization of tissues and organs within the body. Photoacoustic tomography generates high-resolution images of blood-rich tissues without the need for exogenous contrast agents. PhotoSound Product Used TriTom Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot Photoacoustic tomography to assess […]
Tag: in vivo
Therapeutic Monitoring
PhotoSounds OEM Line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage. PhotoSound’s ADCs are feature-rich, they have multiple electronic and […]
CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN
Authors: Diego S. Dumani1,2, Hans-Peter Brecht3, Vassili Ivanov3, Ryan Deschner4, Justin T. Harris4, Kimberly A. Homan4, Jason R. Cook5, Stanislav Y. Emelianov1,2, Sergey A. Ermilov3 ABSTRACT We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition […]
COMMERCIAL SMALL ANIMAL IMAGING COULD AID DISEASE DETECTION
Authors: Mark Little ABSTRACT The development of anticancer metastatic therapies for human clinical trials requires meticulous evaluation of efficacy and optimization of small animal test models in preclinical experimentation. Critical information on morphology and the molecular microenvironment of tumors is currently obtained and monitored using noninvasive, in vivo imaging methods. Detection of individual, small tumors […]
A PRECLINICAL SMALL ANIMAL IMAGING PLATFORM COMBINING MULTI-ANGLE PHOTOACOUSTIC AND FLUORESCENCE PROJECTIONS INTO CO-REGISTERED 3D MAPS
Authors: Weylan Thompson1, Anthony Yu2,3, Diego S. Dumani2,3,4, Jason Cook5, Mark A. Anastasio6, Stanislav Y. Emelianov2,3, Sergey A. Ermilov1 ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
DUAL-MODALITY X-RAY-INDUCED RADIATION ACOUSTIC AND ULTRASOUND IMAGING FOR REAL-TIME MONITORING OF RADIOTHERAPY
Authors: Wei Zhang,1 Ibrahim Oraiqat,2 Hao Lei,3 Paul L. Carson,1,4 Issam EI Naqa,2 and Xueding Wang1,4 ABSTRACT Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) […]
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kima,b, Anthony M Yua, Kelsey P. Kubelicka,b, Stanislav Y. Emelianova,b ABSTRACT Matrix metalloproteinase-9 (MMP-9) plays major roles in extracellular matrix (ECM) remodeling and membrane protein cleavage, suggesting a high correlation with cancer cell invasion and tumor metastasis. Here, we present a contrast agent based on a DNA aptamer that can selectively target human […]
PHOTOACOUSTIC TOMOGRAPHY TO ASSESSACUTE VASOACTIVITY OF SYSTEMIC VASCULATURE
Author(s): Huda, Kristieª; Lawrence, Dylanª; Lindsey, Sarah; Bayer, Carolynª* ABSTRACT Vasoactivity is an important physiological indicator of cardiovascular health which is frequently measured using ex vivo vessels to determine functional mechanisms and evaluate pharmacological responses. Currently, there are no imaging methods available to assess vasoactivity in multiple vascular beds of living animals noninvasively. In this […]
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Authors: Hengrong Lana,b,c,1, Daohuai Jianga,b,c,1, Feng Gaoa, Fei Gaoa,* ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. […]