Author(s):Vinoin Devpaul Vincely, Xingjian Zhong, Kristie Huda, Swathi P. Katakam, Joshua C. Kays, Allison M. Dennis, Carolyn L. Bayer ABSTRACT In this study, we demonstrate the potential of the bornite crystal structure (Cu5FeS4) of copper iron sulfide as a second near infrared (NIR-II) photoacoustic (PA) contrast agent. Bornite exhibits comparable dose-dependent biocompatibility to copper sulfide nanoparticles in a cell viability study with HepG2 cells, while exhibiting a 10-fold increase […]
Tag: molecular imaging
On the importance of low-frequency signals in functional and molecular photoacoustic computed tomography
Author(s): Tri Vu, Paul Klippel, Aidan J. Canning, Chenshuo Ma, Huijuan Zhang, Ludmila A. Kasatkina, Yuqi Tang, Jun Xia, Vladislav V. Verkhusha, Tuan Vo-Dinh, Yun Jing, Junjie Yao ABSTRACT In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes […]
Phototherapy mode control by tuning molecular and supramolecular forms of indocyanine green in crosslinked polyion complex nanoparticles
Author(s): Aixa Aguilera-Garrido, Marie Millard, Mathilde Bouché, Pascal Lemière, Nadia Canilho, Andreea Pasc, Kazunori Kataoka, Joachim F.R. Van Guyse, Henri-Pierre Lassalle, Yann Bernhard ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for treating hypoxic tumors, while photodynamic therapy (PDT) is limited by its oxygen dependence. Indocyanine green (ICG) is a clinically approved near-infrared (NIR) […]
Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging
Author(s): F. Ghane Golmohamadi, A. Mehmood, H. T. Phan, F.-J. Schmitt, and J. Laufer ABSTRACT Pump-probe excitation of fluorophores has been shown to overcome the limitations of conventional multiwavelength imaging and linear unmixing approaches by providing fluorophore-specific contrast whilst eliminating the dominant background signal of endogenous chromophores. In this study, methods for generating pump-probe signals and images are […]
A 3D IMAGING SYSTEM INTEGRATING PHOTOACOUSTIC AND FLUORESCENCE ORTHOGONAL PROJECTIONS FOR ANATOMICAL, FUNCTIONAL, AND MOLECULAR ASSESSMENT OF RODENT MODELS
Authors: Hans P. Brecht, Vassili Ivanov, Diego S. Dumani, Stanislav Y. Emelianov, Mark A. Anastasio, Sergey A. Ermilov ABSTRACT We have developed a preclinical 3D imaging instrument integrating photoacoustic tomography and fluorescence (PAFT) addressing known deficiencies in sensitivity and spatial resolution of the individual imaging components. PAFT is designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal projections at each […]
