Author(s): Gong, Linghui and Cai, Chao and Lin, Fukang and Xu, Zequan and Wang, Zhaoyu and Li, Hui and Liu, Yubin
ABSTRACT
In this study, we utilized a home-made photoacoustic tomography system to recover optical absorption coefficient and elastic modulus under single wavelength. To reconstruct the optical absorption coefficient from photoacoustic measurements, we amalgamate the finite element solutions to the photoacoustic wave equation with MC simulation. Upon determining the absorption coefficient, the elastic modulus reconstruction relies on the analysis of the photoacoustic elastic tomography wave equation. In ex vivo trials, quantitative pencil lead and porcine liver tissue showed an absorption coefficient of 5015±5mm-1 and 0.236±0.01mm-1 at the wavelength of 800nm, respectively, while their elastic modulus parameters were 45.5±0.5GPa and 2.5±0.2GPa. Additionally, we implemented this methodology on in vivo three-dimensional quantitative finger imaging, obtaining the distribution of three-dimensional vascular absorption coefficients and elasticity modulus of the finger at the wavelength of 800nm. From these results, we confirm the method’s capability to discern differences in optical and acoustic properties between normal and abnormal tissues.