Author(s): Margarita R. Chetyrkina, Julijana Cvjetinovic, Fedor S. Fedorov, Stanislav V. Perevoschikov, Ekaterina S., Prikhozhdenko,Bjørn F. Mikladal, Yuri G. Gladush, Albert G. Nasibulin,Dmitry A. Gorin ABSTRACT Optoacoustic (photoacoustic) imaging has gained tremendous attention in research and in clinical practice as a point-of-care system for noninvasive, fast, and safe tests. The first optoacoustic (OA) tomograph has […]
Author: PhotoSound
Targeted contrast agents and activatable probes for photoacoustic imaging of cancer
Author(s): Zhenxiang Zhao, Chelsea Swartchick, Jefferson Chan ABSTRACT Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution visualization of biological processes within deep tissue. Through the development and application of exogenous targeted contrast agents and activatable probes that can respond to a given cancer biomarker, researchers can image molecular events in vivo during cancer progression. […]
Commercial Small Animal Imaging Could Aid Disease Detection
Author(s): Mark Little ABSTRACT The development of anticancer metastatic therapies for human clinical trials requires meticulous evaluation of efficacy and optimization of small animal test models in preclinical experimentation1. Critical information on morphology and the molecular microenvironment of tumors is currently obtained and monitored using noninvasive, in vivo imaging methods. Detection of individual, small tumors […]
Assessment of a Single-Element Scanning System for Enhanced Photoacoustic Imaging of Brain Hemorrhage
Author(s): Juliana Benavides Lara, Ravi Prakash, Kamran Avanaki ABSTRACT The use of photoacoustic brain imaging for hemorrhage detection holds significant clinical importance. This study focuses on the performance of sensitivity and detection capabilities of a single-element scanning system, considering the remarkable signal-to-noise ratio of photoacoustic signals generated by a single-element transducer. By employing blood vessel-like phantoms and […]
High-throughput photoacoustic tomography by integrated robotics and automation
Author(s): N. Marshall, H.-P. Brecht, W. Thompson, D. Lawrence, V. Marshall, S. Toler, S. Emelianov, A. Yu, M. A. Anastasio, U. Villa, J. Maxwell, and S. Ermilov ABSTRACT We present the development of a photoacoustic tomography (PAT) imaging system with the demonstrated capability of obtaining high-throughput scans at a sustained rate of under 1 minute […]
In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice
Author(s): Kristie Huda, Dylan J. Lawrence, Weylan Thompson, Sarah H. Lindsey & Carolyn L. Bayer ABSTRACT Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases, and many therapies are therefore targeted to the vasculature. Therapeutics which are selective for the diseased vasculature are ideal, but whole-body selectivity of a therapeutic is challenging to assess […]
PhotoSound Will be exhibiting at the upcoming BIOS Exhibition
PhotoSound will be exhibiting at the upcoming BIOS Exhibition during the Photonics West conference. Meet Sam and Peter at Booth 8559 on January 17th and 18th at the Moscone Center in San Francisco
Radiomics-driven perfusion prediction in clinical photoacoustic foot imaging
Author(s): Chuqin Huang a, Yanda Cheng a, Xiaoyu Zhang b, Ye Zhan c, Wenhan Zheng a, Isabel Komornicki d, Linda M. Harris d, Wenyao Xu b, Jun Xia a ABSTRACT Accurate assessment of tissue perfusion is essential for managing chronic foot ulcers in patients with diabetes and peripheral arterial disease. While photoacoustic (PA) imaging enables high-resolution […]
Investigating the Impact of Prenatal Alcohol Exposure on Fetal Cardiac Development Using Photoacoustic Tomography
Author(s): M. F. Tanvir, H. Yang, J. D. Gardner, and H. Jiang ABSTRACT Prenatal alcohol exposure (PAE) is a leading cause of developmental abnormalities, yet its effects on fetal cardiac development remain understudied. We employed real-time, label-freemultispectral photoacoustic tomography (PAT) to noninvasively assess cardiac development in mouse fetuses exposed to chronic alcohol. Using a custom-built […]
Direct Monitoring of Whole-Brain Electrodynamics via High-Spatiotemporal-Resolution Photoacoustics with Voltage-Sensitive Dye
Author(s): W. Pang, B. Zhu, H. Li, Y. Zhou, C. M. Woo, X. Huang, T. Zhong, H. Lo, L. Wang, P. Lai, and L. Nie ABSTRACT This work proposes a novel method for monitoring deep-brain electrodynamics with a voltage-sensitive dye (VSD)-based photoacoustic imaging platform, called PA-VSD. This platform is demonstrated to allow for effectively localizing […]
