Author(s): Huda, Kristieª; Lawrence, Dylanª; Lindsey, Sarah; Bayer, Carolynª* ABSTRACT Vasoactivity is an important physiological indicator of cardiovascular health which is frequently measured using ex vivo vessels to determine functional mechanisms and evaluate pharmacological responses. Currently, there are no imaging methods available to assess vasoactivity in multiple vascular beds of living animals noninvasively. In this […]
Tag: photoacoustic tomography
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Authors: Hengrong Lana,b,c,1, Daohuai Jianga,b,c,1, Feng Gaoa, Fei Gaoa,* ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. […]
PHOTOACOUSTIC IMAGING FOR IN VIVO QUANTIFICATION OF ALCOHOL-INDUCED STRUCTURAL AND FUNCTIONAL CHANGES IN CEREBRAL VASCULATURE IN HIGH ALCOHOL-PREFERRING MICE (HAP)
Authors: Augustine Meombe Mbolle, Hao Yang, Huabei Jiang* ABSTRACT Alcohol-induced structural and functional changes were studied in vivo by photoacoustic tomography (PAT) of the cerebrovascular system in selectively bred alcohol-preferring mice. High (HAP) and low (LAP) alcohol-preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to […]
SIZE-ADJUSTABLE RING-SHAPE PHOTOACOUSTIC TOMOGRAPHY IMAGER IN VIVO
Author(s): Daohuai Jiang1,2,3, Yifei Xu1, Hengrong Lan1,2,3, Yuting Shen1, Yifan Zhang1,Feng Gao1, Li Liu4*, Fei Gao1,5* ABSTRACT Photoacoustic tomography (PAT) has become a novel biomedical imaging modality for scientific research and clinical diagnosis. It combines the advantages of spectroscopic optical absorption contrast and acoustic resolution with deep penetration. In this article, an imaging size-adjustable PAT […]
NON-INVASIVE PHOTOACOUSTIC COMPUTED TOMOGRAPHY OF RAT HEART ANATOMY AND FUNCTION
Author(s): Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson, Lihong V. Wang ABSTRACT Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional optical contrast. However, PAT has not been demonstrated to […]
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Author(s): Hengrong Lan, Daohuai Jiang, Feng Gao, Fei Gao ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. To reduce the channel number of DAQ, we superimpose 30 nearby […]
Y-NET: HYBRID DEEP LEARNING IMAGE RECONSTRUCTION FOR PHOTOACOUSTIC TOMOGRAPHY IN VIVO
Author(s): Hengrong Lan, Daohuai Jiang, Changchun Yang, Feng Gao, Fei Gao ABSTRACT Conventional reconstruction algorithms (e.g., delay-and-sum) used in photoacoustic imaging (PAI) provide a fast solution while many artifacts remain, especially for limited-view with ill-posed problem. In this paper, we propose a new convolutional neural network (CNN) framework Y-Net: a CNN architecture to reconstruct the initial PA pressure distribution by optimizing both raw data and beamformed images […]
AUTOMATIC FORCE-CONTROLLED 3D PHOTOACOUSTIC SYSTEM FOR HUMAN PERIPHERAL VASCULAR IMAGING
Author(s): David C. Garrett, Jinhua Xu, Geng Ku, and Lihong V. Wang ABSTRACT We developed a system for whole-body human ultrasound tomography in reflection and transmission modes. A custom 512-element ultrasound receiver array with a rotating single-element ultrasound transmitter are used to generate 2D isotropically resolved images across the entire human cross-section. We demonstrate this […]
DUAL-SCAN PHOTOACOUSTIC TOMOGRAPHY FOR THE IMAGING OF VASCULAR STRUCTURE ON FOOT
Author(s): Chuqin Huang, Yanda Cheng, Wenhan Zheng, Robert W Bing, Huijuan Zhang, Isabel Komornicki, Linda M Harris, Praveen R Arany, Saptarshi Chakraborty, Qifa Zhou, Wenyao Xu, Jun Xia ABSTRACT Chronic leg ulcers are affecting approximately 6.5 million Americans, and they are associated with significant mortality, reduced quality of life, and high treatment costs. Since many […]
HIGH-SPEED THREE-DIMENSIONAL PHOTOACOUSTIC COMPUTED TOMOGRAPHY FOR PRECLINICAL RESEARCH AND CLINICAL TRANSLATION
Authors: Li Lin1,4, Peng Hu1,4, Xin Tong1,4, Rui Cao1, Xiaoyun Yuan1,2, David C. Garrett1, Junhui Shi1,3, Konstantin Maslov1 & Lihong V. Wang1 ABSTRACT Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications […]