Author(s): Weylan Thompson, Hans-Peter Brecht, Sergey A. Ermilov, Vassili Ivanov ABSTRACT We present the continued development of a clinical ultrasound (US) imaging device with a photoacoustic (PA) mode. The combined USPA imaging platform is designed around a compact US component capable of B-mode, M-mode, color Doppler, and pulsed wave Doppler US imaging modes with a 128-element US probe. […]
Tag: preclinical research
A 3D IMAGING SYSTEM INTEGRATING PHOTOACOUSTIC AND FLUORESCENCE ORTHOGONAL PROJECTIONS FOR ANATOMICAL, FUNCTIONAL, AND MOLECULAR ASSESSMENT OF RODENT MODELS
Authors: Hans P. Brecht, Vassili Ivanov, Diego S. Dumani, Stanislav Y. Emelianov, Mark A. Anastasio, Sergey A. Ermilov ABSTRACT We have developed a preclinical 3D imaging instrument integrating photoacoustic tomography and fluorescence (PAFT) addressing known deficiencies in sensitivity and spatial resolution of the individual imaging components. PAFT is designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal projections at each […]
Photoacoustic Volume Rendering Maximum Intensity Projection of a Mouse’s Lower Thorax
TriTom Photoacoustic Fluorescent Hybrid Image of a Mouse
TriTom Photoacoustic Image of Mouse
TriTom Image of Mouse at 890nm
TriTom Whole-Body 3D Image of a Mouse
COMMERCIAL SMALL ANIMAL IMAGING COULD AID DISEASE DETECTION
Authors: Mark Little Photoacoustic and optical images of the ventrodorsal view of a mouse specimen: 532 nm (yellow, skin level) + 890 nm (red, deep anatomy) (a); 532 nm (yellow, skin level) + 780 nm (green, ICG detecting) (b) and 532 nm (yellow, skin level) + 780 nm (green, ICG detecting) + FMT (blue, 780-nm excitation) (c). Injection site, […]
A PRECLINICAL SMALL ANIMAL IMAGING PLATFORM COMBINING MULTI-ANGLE PHOTOACOUSTIC AND FLUORESCENCE PROJECTIONS INTO CO-REGISTERED 3D MAPS
Authors: Weylan Thompson, Anthony Yu, Diego S. Dumani, Jason Cook, Mark A. Anastasio, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
