Tag: preclinical research

Spatiotemporal Image Reconstruction to Enable High-Frame-Rate Dynamic Photoacoustic Tomography with Rotating-Gantry Volumetric Imagers

Author(s): Refik Mert Cam, Chao Wang, Weylan Thompson, Sergey A. Ermilov, Mark A. Anastasio, Umberto Villa ABSTRACT Significance Dynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, current dynamic PACT imaging techniques are often limited to two-dimensional spatial imaging. Although volumetric PACT imagers are commercially available, these systems typically employ a rotating measurement gantry […]

SIZE-TUNABLE ICG-BASED CONTRAST AGENT PLATFORM FOR TARGETED NEAR-INFRARED PHOTOACOUSTIC IMAGING

2022 Dec 11 Author(s): Shrishti Singh, Giovanni Giammanco, Chih-Hsiang Hu, Joshua Bush, Leandro Soto Cordova, Dylan J Lawrence, Jeffrey L Moran, Parag V Chitnis, Remi Veneziano ABSTRACT Near-infrared photoacoustic imaging (NIR-PAI) combines the advantages of optical and ultrasound imaging to provide anatomical and functional information of tissues with high resolution. Although NIR-PAI is promising, its widespread use is hindered by […]

FUNCTIONAL PHOTOACOUSTIC IMAGING FOR PLACENTAL MONITORING: A MINI REVIEW

available on 2024-09-29 Author(s): Vinoin Devpaul Vincely, Carolyn L Bayer ABSTRACT The placenta, a highly vascularized interface between the mother and fetus, undergoes dramatic anatomical and functional changes during pregnancy. These changes occur both during healthy development and adverse pathologies of pregnancy, such as preeclampsia. Abnormal placental development can lead to life-long health impacts on both the […]

NON-INVASIVE 3D PHOTOACOUSTIC TOMOGRAPHY OF ANGIOGRAPHIC ANATOMY AND HEMODYNAMICS OF FATTY LIVERS IN RATS

17 November 2022 Author(s): Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson,and Lihong V. Wang ABSTRACT Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional […]

A COMBINED ULTRASOUND AND PHOTOACOUSTIC IMAGING PLATFORM FOR CLINICAL RESEARCH APPLICATIONS

3 March 2022 Author(s): Weylan Thompson, Hans-Peter Brecht, Sergey A. Ermilov, Vassili Ivanov ABSTRACT We present the continued development of a clinical ultrasound (US) imaging device with a photoacoustic (PA) mode. The combined USPA imaging platform is designed around a compact US component capable of B-mode, M-mode, color Doppler, and pulsed wave Doppler US imaging modes with a […]

A 3D IMAGING SYSTEM INTEGRATING PHOTOACOUSTIC AND FLUORESCENCE ORTHOGONAL PROJECTIONS FOR ANATOMICAL, FUNCTIONAL, AND MOLECULAR ASSESSMENT OF RODENT MODELS

16 March 2018 Authors: Hans P. Brecht, Vassili Ivanov, Diego S. Dumani, Stanislav Y. Emelianov, Mark A. Anastasio, Sergey A. Ermilov ABSTRACT We have developed a preclinical 3D imaging instrument integrating photoacoustic tomography and fluorescence (PAFT) addressing known deficiencies in sensitivity and spatial resolution of the individual imaging components. PAFT is designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal […]