Author(s): Aixa Aguilera-Garrido, Marie Millard, Mathilde Bouché, Pascal Lemière, Nadia Canilho, Andreea Pasc, Kazunori Kataoka, Joachim F.R. Van Guyse, Henri-Pierre Lassalle, Yann Bernhard ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for treating hypoxic tumors, while photodynamic therapy (PDT) is limited by its oxygen dependence. Indocyanine green (ICG) is a clinically approved near-infrared (NIR) […]
Tag: TriTom
Quantitative photoacoustic tomography of skin vasculature predicts subcutaneous implant exposure
Author(s): A. M. Yu, X. Huang, S. M. A. Morais, J. H. Park, D. A. Zopf, S. J. Hollister, and S. Emelianov ABSTRACT Craniofacial implants are prone to skin necrosis and exposure, likely due to implant-induced stress and ischemia. However, this relationship has not been quantitatively validated. Identifying an imaging biomarker of skin vascular health […]
Dual photoacoustic/ultrasound technologies for preclinical research: current status and future trends
Author(s): M. Pérez-Liva, M. Alonso de Leciñana, M. Gutiérrez-Fernández, J. Camacho Sosa Dias, J. F. Cruza, J. Rodríguez-Pardo, I. García-Suárez, F. Laso-García, J. L. Herraiz, and L. Elvira Segura ABSTRACT Photoacoustic (PA) imaging, by integrating optical and ultrasound (US) modalities, combines high spatial resolution with deep tissue penetration, making it a transformative tool in biomedical […]
Bornite (Cu5FeS4) nanocrystals as an ultrasmall biocompatible NIR-II contrast agent for photoacoustic imaging
Author(s):Vinoin Devpaul Vincely, Xingjian Zhong, Kristie Huda, Swathi P. Katakam, Joshua C. Kays, Allison M. Dennis, Carolyn L. Bayer ABSTRACT In this study, we demonstrate the potential of the bornite crystal structure (Cu5FeS4) of copper iron sulfide as a second near infrared (NIR-II) photoacoustic (PA) contrast agent. Bornite exhibits comparable dose-dependent biocompatibility to copper sulfide nanoparticles in a cell viability study with HepG2 cells, while exhibiting a 10-fold increase […]
Carbon Nanotube Microscale Fiber Grid as an Advanced Calibration System for Multispectral Optoacoustic Imaging
Author(s): Margarita R. Chetyrkina, Julijana Cvjetinovic, Fedor S. Fedorov, Stanislav V. Perevoschikov, Ekaterina S., Prikhozhdenko,Bjørn F. Mikladal, Yuri G. Gladush, Albert G. Nasibulin,Dmitry A. Gorin ABSTRACT Optoacoustic (photoacoustic) imaging has gained tremendous attention in research and in clinical practice as a point-of-care system for noninvasive, fast, and safe tests. The first optoacoustic (OA) tomograph has […]
Targeted contrast agents and activatable probes for photoacoustic imaging of cancer
Author(s): Zhenxiang Zhao, Chelsea Swartchick, Jefferson Chan ABSTRACT Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution visualization of biological processes within deep tissue. Through the development and application of exogenous targeted contrast agents and activatable probes that can respond to a given cancer biomarker, researchers can image molecular events in vivo during cancer progression. […]
Commercial Small Animal Imaging Could Aid Disease Detection
Author(s): Mark Little ABSTRACT The development of anticancer metastatic therapies for human clinical trials requires meticulous evaluation of efficacy and optimization of small animal test models in preclinical experimentation1. Critical information on morphology and the molecular microenvironment of tumors is currently obtained and monitored using noninvasive, in vivo imaging methods. Detection of individual, small tumors […]
High-throughput photoacoustic tomography by integrated robotics and automation
Author(s): N. Marshall, H.-P. Brecht, W. Thompson, D. Lawrence, V. Marshall, S. Toler, S. Emelianov, A. Yu, M. A. Anastasio, U. Villa, J. Maxwell, and S. Ermilov ABSTRACT We present the development of a photoacoustic tomography (PAT) imaging system with the demonstrated capability of obtaining high-throughput scans at a sustained rate of under 1 minute […]
In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice
Author(s): Kristie Huda, Dylan J. Lawrence, Weylan Thompson, Sarah H. Lindsey & Carolyn L. Bayer ABSTRACT Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases, and many therapies are therefore targeted to the vasculature. Therapeutics which are selective for the diseased vasculature are ideal, but whole-body selectivity of a therapeutic is challenging to assess […]
Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging
Author(s): F. Ghane Golmohamadi, A. Mehmood, H. T. Phan, F.-J. Schmitt, and J. Laufer ABSTRACT Pump-probe excitation of fluorophores has been shown to overcome the limitations of conventional multiwavelength imaging and linear unmixing approaches by providing fluorophore-specific contrast whilst eliminating the dominant background signal of endogenous chromophores. In this study, methods for generating pump-probe signals and images are […]
