Author: PhotoSound

Contrast Agent Development Application Note

TriTomTM Contrast Agent Develpoment The development of novel optical imaging contrast agents requires extensive testing in both phantoms and animal models to ensure the safety and utility of the agent for in vivo applications. However, evaluating the biodistribution and clearance of a contrast agent remains challenging in preclinical studies due to limited whole-body real-time imaging […]

Anatomical Imaging Application Note

TriTom™ Photoacoustic Imaging Platform: Small Animal Anatomical Imaging The ability to directly visualize and evaluate anatomical structures and biological processes in small animal models at the whole-body level is critical for understanding the pathophysiology of human diseases. The TriTom™ small animal imaging platform provides noninvasive high-resolution photoacoustic tomography (PAT) images that can be used to extract functional and […]

Brain Imaging Application Note

Photoacoustic Neuroimaging with the TriTomTM Brain imaging, or neuroimaging, is used to understand the relationship between brain function and behavior and study the underlying causes of neurological and psychiatric diseases. It is important in helping to understand the relationship between specific areas of the brain and what function they serve. Photoacoustic Imaging (PAI) relies on differential […]

Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS-Independent Antibacterial Properties Promote Diabetic Wound Healing

Author(s): Yaru Guo, Shuai Ding, Changshuai Shang, Chenguang Zhang, Menggang Li, Qinghua Zhang, Lin Gu, Boon Chin Heng, Shihan Zhang, Feng Mei, Ying Huang, Xuehui Zhang, Mingming Xu, Jiuhui Jiang, Shaojun Guo, Xuliang Deng, Lili Chen Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)-scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving the catalytic efficiency of Pt-based nanozymes (e.g., PtCu, […]

Cancer Imaging Application Note

Cancer Detection and Monitoring with the TriTomTM Photoacoustic imaging has become a popular tool in preclinical cancer research as a noninvasive technique for monitoring tumor growth and therapeutic response. Specifically, photoacoustic imaging can provide high-sensitivity images of both superficial and deep vasculature and quantitative assessment of blood oxygen saturation without exogenous contrast. The TriTom small […]

Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

Author(s): Iaroslav B. Belyaev, Ivan V. Zelepukin, Polina A. Kotelnikova, Gleb V. Tikhonowski, Anton A. Popov, Alina Yu. Kapitannikova, Jugal Barman, Alexey N. Kopylov, Daniil N. Bratashov, Ekaterina S. Prikhozhdenko, Andrei V. Kabashin, Sergey M. Deyev, Andrei V. Zvyagin Abstract Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical […]

The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

Author(s): Wei Zhang, Dale Litzenberg, Yaocai Huang, Kai-Wei Chang, Ibrahim Oraiqat, Scott Hadley, Eduardo G. Moros, Man Zhang, Paul L. Carson, Kyle C. Cuneo, Issam EI Naqa, Xueding Wang Abstract Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is the development of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition […]

Toward in vivo dosimetry in external beam radiotherapy using x-ray acoustic computed tomography: A soft-tissue phantom study validation

Author(s): Hao Lei, Wei Zhang, Ibrahim Oraiqat, Zhipeng Liu, Jun Ni, Xueding Wang, Issam El Naqa Abstract Purpose: To study, using phantoms made from biological tissues, the feasibility and practical challenges of monitoring the position of the radiation beam and the deposited dose by x-ray acoustic computed tomography (XACT) during external beam radiotherapy delivery. Material and methods: A prototype XACT system […]

Custom Systems & Algorithms

PhotoSounds OEM line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage. PhotoSound’s ADCs are feature-rich, they have multiple electronic and […]

GPU-Accelerated 3D Volumetric X-Ray-Induced Acoustic Computed Tomography

Author(s): Donghyun Lee, Eun-Yeong Park, Seongwook Choi, Hyeongsub Kim, Jung-joon Min, Changho Lee, and Chulhong Kim ABSTRACT X-ray acoustic imaging is a hybrid biomedical imaging technique that can acoustically monitor X-ray absorption distribution in biological tissues through the X-ray induced acoustic effect. In this study, we developed a 3D volumetric X-ray-induced acoustic computed tomography (XACT) […]