Tag: Photoacoustic Imaging

REAL-TIME PHOTOACOUSTIC DATA ACQUISITION WITH A THOUSAND PARALLEL CHANNELS AT HUNDREDS FRAMES PER SECOND

Authors: Vassili Ivanov, Hans Peter Brecht, Sergey A. Ermilov ABSTRACT Large number of simultaneously acquired spatially distinct pressure signals is required to improve quality of real-time photoacoustic and x-ray acoustic biomedical images [1]. In the past this approach was limited by availability of commercial multi-channel analog-to-digital converter (ADC) systems and ability to operate multiple ADC […]

CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN

Authors: Diego S. Dumani, Hans-Peter Brecht, Vassili Ivanov, Ryan Deschner, Justin T. Harris, Kimberly A. Homan, Jason R. Cook, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition […]

MASSIVE PARALLEL ULTRASOUND AND PHOTOACOUSTIC PC-BASED SYSTEM

Authors: Weylan Thompson, Hans Peter Brecht, Sergey Ermilov, Vassili Ivanov ABSTRACT PhotoSound Technologies specializes in the development of electronics solutions for massive parallel data acquisition applicable to the fields of photoacoustics (PA), X-ray acoustics, including 3D dosimetry, and ultrasound. PhotoSound’s Legion ADC256 R1.1, released in 2018, is a 256-channel 12-bit ADC with a sampling rate […]

A PRECLINICAL SMALL ANIMAL IMAGING PLATFORM COMBINING MULTI-ANGLE PHOTOACOUSTIC AND FLUORESCENCE PROJECTIONS INTO CO-REGISTERED 3D MAPS

Authors: Weylan Thompson, Anthony Yu, Diego S. Dumani, Jason Cook, Mark A. Anastasio, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]

PHOTOACOUSTIC IMAGE-GUIDED DELIVERY OF PLASMONIC-NANOPARTICLE-LABELED MESENCHYMAL STEM CELLS TO THE SPINAL CORD

Authors: Eleanor M. Donnelly, Kelsey P. Kubelick, Diego S. Dumani, and Stanislav Y. Emelianov ABSTRACT Regenerative therapies using stem cells have great potential for treating neurodegenerative diseases and traumatic injuries in the spinal cord. In spite of significant research efforts, many therapies fail at the clinical phase. As stem cell technologies advance toward clinical use, […]

TECHNICAL CONSIDERATIONS IN THE VERASONICS RESEARCH ULTRASOUND PLATFORM FOR DEVELOPING A PHOTOACOUSTIC IMAGING SYSTEM

Authors: Karl Kratkiewicz, Rayyan Manwar, Yang Zhou, Moein Mozaffarzadeh, Kamran Avanaki Fig. 10. PA signal amplification. (A) System setup to test the Photosound AMP128-18 amplifier: (i) display monitor, (ii) Nd:YAG laser head, (iii) fiber optic bundle, (iv) laser power supply, (v) laser chiller. (B) Wire imaging results: wire phantom suspended in 0% intralipid imaged (i) without […]