Authors: Karl Kratkiewicz, Rayyan Manwar, Yang Zhou, Moein Mozaffarzadeh, Kamran Avanaki
Fig. 10. PA signal amplification. (A) System setup to test the Photosound AMP128-18 amplifier: (i) display monitor, (ii) Nd:YAG laser head, (iii) fiber optic bundle, (iv) laser power supply, (v) laser chiller. (B) Wire imaging results: wire phantom suspended in 0% intralipid imaged (i) without and (iv) with amplifier, wire phantom suspended in 25% intralipid imaged (ii) without and (v) with amplifier, and wire phantom suspended in 50% intralipid image (iii) without and (vi) with amplifier. (C) Raw data from the 64th channel of the linear array when imaging a single wire in 50% intralipid concentration to demonstrate SNR improvement from (i) without amplifier (SNR: 3.25 dB) to (ii) with amplifier (SNR: 5.5 dB), (D) Bar chart demonstrating signal amplitude increase corresponding to phantom imaging in B with and without amplifier, at different concentrations of intralipid.
ABSTRACT
Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the vantage system from Verasonics for simultaneous ultrasound (US) and photoacoustic (PA) imaging. This was the motivation to write on the details of US/PA imaging system implementation and characterization using Verasonics platform. We have discussed the experimental considerations for linear array based PAI due to its popularity, simple setup, and high potential for clinical translatability. Specifically, we describe the strategies of US/PA imaging system setup, signal generation, amplification, data processing and study the system performance.
Citation
K. Kratkiewicz, R. Manwar, Y. Zhou, M. Mozaffarzadeh, and K. Avanaki, “Technical Considerations in the Verasonics Research Ultrasound Platform for Developing a Photoacoustic Imaging System,” Biomedical Optics Express, vol. 12, no. 2, pp. 1050-1084, 2021, doi: 10.1364/BOE.415481.
