Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
Tag: Photoacoustic Imaging
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kim, Anthony M Yu, Kelsey P. Kubelick, Stanislav Y. Emelianov Fig. 5. Spectroscopic analysis and PAT of the MMP sensor in an in vivo mouse model of breast cancer. (a) PA intensity from 680 nm to 970 nm of the MMP sensor in the tumor region and assorted controls – saline only and control sensor. Black dashed line […]
BREAKTHROUGH INSTRUMENTS AND PRODUCTS PHOTOSONUS M+ LASER FOR PHOTOACOUSTIC IMAGING
Authors: Aldas Juronis and Mantvydas Jašinskas Fig 2. A small animal whole body in vivo imaging platform TriTom based on photoacoustic fluorescence tomography with an integrated PhotoSonus M laser system. Courtesy of PhotoSound Technologies, Inc. ABSTRACT This report highlights PhotoSonus M+, a tunable wavelength laser system recently introduced and developed specifically for photoacoustic imaging applications, where the highest imaging depth and […]
PHOTOACOUSTIC IMAGING FOR IN VIVO QUANTIFICATION OF ALCOHOL-INDUCED STRUCTURAL AND FUNCTIONAL CHANGES IN CEREBRAL VASCULATURE IN HIGH ALCOHOL-PREFERRING MICE (HAP)
Authors: Augustine Meombe Mbolle, Hao Yang, Huabei Jiang* ABSTRACT Alcohol-induced structural and functional changes were studied in vivo by photoacoustic tomography (PAT) of the cerebrovascular system in selectively bred alcohol-preferring mice. High (HAP) and low (LAP) alcohol-preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to […]
TRANSFONTANELLE PHOTOACOUSTIC IMAGING: ULTRASOUND TRANSDUCER SELECTION ANALYSIS
Authors: Rayyan Manwar, Tarikul Islam, MD, Seyed Mohsen Ranjbaran, Kamran Avanaki ABSTRACT Transfontanelle ultrasound imaging (TFUI) is the conventional approach for diagnosing brain injury in neonates. Despite being the first stage imaging modality, TFUI lacks accuracy in determining the injury at an early stage due to degraded sensitivity and specificity. Therefore, a modality like photoacoustic […]
SIZE-ADJUSTABLE RING-SHAPE PHOTOACOUSTIC TOMOGRAPHY IMAGER IN VIVO
Author(s): Daohuai Jiang1,2,3, Yifei Xu1, Hengrong Lan1,2,3, Yuting Shen1, Yifan Zhang1,Feng Gao1, Li Liu4*, Fei Gao1,5* ABSTRACT Photoacoustic tomography (PAT) has become a novel biomedical imaging modality for scientific research and clinical diagnosis. It combines the advantages of spectroscopic optical absorption contrast and acoustic resolution with deep penetration. In this article, an imaging size-adjustable PAT […]
NON-INVASIVE PHOTOACOUSTIC COMPUTED TOMOGRAPHY OF RAT HEART ANATOMY AND FUNCTION
Author(s): Li Lin, Xin Tong, Susana Cavallero, Yide Zhang, Shuai Na, Rui Cao, Tzung K. Hsiai, and Lihong V. Wang ABSTRACT Photoacoustic computed tomography (PACT) combines optical contrast with acoustic-resolution imaging, but non-invasive cardiac imaging with this technique has been limited by signal loss and distortion caused by the chest wall. This work presents a […]
MONITORING NEONATAL BRAIN HEMORRHAGE PROGRESSION BY PHOTOACOUSTIC TOMOGRAPHY
Author(s): Tianqi Shan, Hao Yang, Shixie Jiang, and Huabei Jiang ABSTRACT Neonatal brain hemorrhage (NBH) is the most common neurological disorder in neonates and its clinical interventions are very limited. Understanding the pathology of NBH by non-invasive in-vivo characterization of standardized animal models is essential for developing potential treatments. Currently, there is no suitable tool […]
CHARACTERIZING A PHOTOACOUSTIC AND FLUORESCENCE IMAGING PLATFORM FOR PRECLINICAL MURINE LONGITUDINAL STUDIES
Author(s): Weylan R. Thompson, Hans-Peter F. Brecht, Vassili Ivanov, Anthony M. Yu, Diego S. Dumani, Dylan J. Lawrence, Stanislav Y. Emelianov, Sergey A. Ermilov PAT volumes and slices of in vivo mouse scans. The top PAT row shows 3D renders of the PAT volumes scanned at wavelengths (a) 532 nm for superficial structures, (b) 710 nm for deep structures with deoxygenated […]
BIODEGRADABLE AND BIOCOMPATIBLE SEMICONDUCTOR NANOCRYSTALS AS NIR-II PHOTOACOUSTIC IMAGING CONTRAST AGENTS
Author(s): Vinoin Devpaul Vincely, Swathi P. Katakam, Kristie Huda, Xingjian Zhong, Joshua C. Kays, Allison M. Dennis, Carolyn L. Bayer ABSTRACT Transabdominal imaging using photoacoustics (PA) is limited by optical attenuation of tissue due to high scattering and absorption in the near infrared (NIR) window. Tissue attenuation is lowered when imaging with longer wavelengths in the NIR window (> 950 nm). […]
