Author(s): Md Farhan Tanvir, Hao Yang, Jason D. Gardner, Huabei Jiang ABSTRACT Prenatal alcohol exposure (PAE) is a leading cause of developmental abnormalities, yet its effects on fetal cardiac development remain understudied. We employed real-time, label-freemultispectral photoacoustic tomography (PAT) to noninvasively assess cardiac development in mouse fetuses exposed to chronic alcohol. Using a custom-built PAT system, […]
Author: PhotoSound
Direct Monitoring of Whole-Brain Electrodynamics via High-Spatiotemporal-Resolution Photoacoustics with Voltage-Sensitive Dye
Author(s): Weiran Pang, Bowen Zhu, Honghui Li, Yingying Zhou, Chi Man Woo, Xiazi Huang, Tianting Zhong, Hsuan Lo, Laiyou Wang, Puxiang Lai, Liming Nie GRAPHICAL ABSTRACT This work proposes a novel method for monitoring deep-brain electrodynamics with a voltage-sensitive dye (VSD)-based photoacoustic imaging platform, called PA-VSD. This platform is demonstrated to allow for effectively localizing epileptic foci and visualizing voltage conduction pathways in a high spatiotemporal […]
Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging
Author(s): Farzin Ghane Golmohamadi, Amna Mehmood, Hoang Trong Phan, Franz-Josef Schmitt, Jan Laufer ABSTRACT Pump-probe excitation of fluorophores has been shown to overcome the limitations of conventional multiwavelength imaging and linear unmixing approaches by providing fluorophore-specific contrast whilst eliminating the dominant background signal of endogenous chromophores. In this study, methods for generating pump-probe signals and images are investigated that […]
Single Wavelength Reconstruction of Optical Absorption Coefficient and Elastic Modulus Utilizing Photoacoustic Tomography
Author(s): Gong, Linghui and Cai, Chao and Lin, Fukang and Xu, Zequan and Wang, Zhaoyu and Li, Hui and Liu, Yubin ABSTRACT In this study, we utilized a home-made photoacoustic tomography system to recover optical absorption coefficient and elastic modulus under single wavelength. To reconstruct the optical absorption coefficient from photoacoustic measurements, we amalgamate the finite […]
3D Frequency-Domain Full Waveform Inversion for Whole-Breast Imaging With a Multi-Row Ring Array
Author(s): Rehman Ali, Gaofei Jin, Melanie Singh, Trevor Mitcham, Nebojsa Duric ABSTRACT For ring-array ultrasound tomography, two-dimensional frequency-domain full waveform inversion is the clinical gold standard for high-resolution imaging of the breast. While yielding high-resolution images in the plane of the ring-array, the resulting slice-wise approach yields lower resolution out of plane when used to reconstruct […]
Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting
Author(s): Chuqin Huang, Emily Zheng, Wenhan Zheng, Huijuan Zhang, Yanda Cheng, Xiaoyu Zhang, Varun Shijo, Robert W. Bing, Isabel Komornicki, Linda M. Harris, Ermelinda Bonaccio, Kazuaki Takabe, Emma Zhang, Wenyao Xu, Jun Xia ABSTRACT Photoacoustic tomography (PAT) is an emerging imaging modality with widespread applications in both preclinical and clinical studies. Despite its promising capabilities to provide high-resolution images, the […]
Utility of Low-Cost Multichannel Data Acquisition System for Photoacoustic Computed Tomography
Author(s): Zafar, Mohsin, Rayyan Manwar, Seyed Mohsen Ranjbaran, and Kamran Avanaki ABSTRACT Typically, multi-single-element photoacoustic computed tomography (PACT) systems utilize numerous ultrasound transducers arranged in cylindrical or hemispherical configurations for detection, combined with a single diffuse light source or multiple sparse light sources to illuminate the imaging target. While these systems produce high-quality 3D PA images, […]
Signal-domain speed-of-sound correction for ring-array-based photoacoustic tomography
Author(s): Daohuai Jiang, Hengrong Lan, Shangqing Tong, Xianzeng Zhang, Fei Gao ABSTRACT Photoacoustic imaging combines the advantages of optical and acoustic imaging, making it a promising tool in biomedical imaging. Photoacoustic tomography (PAT) reconstructs images by solving the inverse problem from detected photoacoustic waves to initial pressure map. The heterogeneous speed of sound (SoS) distribution in biological tissue significantly affects […]
Advancing precision photothermal therapy byintegrating armored gold nanostars with real-timephotoacoustic thermometry and imaging
Author(s): Aidan J. Canning, Tri Vu1, Luca Menozzi, Paul Klippel, Xinrong Chen, Jianing Chen,Theresa Charity, Khang Hoang, Joseph J. Yang, Yun Jing, Gregory M. Palmer5,Junjie Yao1, Tuan Vo-Dinh ABSTRACT Nanoparticle-mediated photothermal therapy (PTT) is a promising strategy for cancer treatment; however,nanoparticle instability and lack of precise imaging tools for real-time temperature monitoring during therapyand nanoparticle tracking […]
Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography
Author(s): Hao Yang, Md Farhan Tanvir, Huabei Jiang Graphical Abstract This study investigates the effects of chronic prenatal alcohol exposure on fetal brain vascular development in mice using photoacoustic tomography. Key vascular parameters such as vessel diameter, density, and oxygen saturation were analyzed from embryonic Days 10 to 20. Results demonstrate significant vascular disruptions in alcohol-exposed […]