Author(s): A. M. Yu, X. Huang, S. M. A. Morais, J. H. Park, D. A. Zopf, S. J. Hollister, and S. Emelianov ABSTRACT Craniofacial implants are prone to skin necrosis and exposure, likely due to implant-induced stress and ischemia. However, this relationship has not been quantitatively validated. Identifying an imaging biomarker of skin vascular health […]
Category: Publication
Phototherapy mode control by tuning molecular and supramolecular forms of indocyanine green in crosslinked polyion complex nanoparticles
Author(s): Aixa Aguilera-Garrido, Marie Millard, Mathilde Bouché, Pascal Lemière, Nadia Canilho, Andreea Pasc, Kazunori Kataoka, Joachim F.R. Van Guyse, Henri-Pierre Lassalle, Yann Bernhard ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for treating hypoxic tumors, while photodynamic therapy (PDT) is limited by its oxygen dependence. Indocyanine green (ICG) is a clinically approved near-infrared (NIR) […]
Nanosecond Pulsed Light Emitting Diode (LED) Based High-Speed Photoacoustic Computed Tomography Using Multiple Single-Element Ultrasound Transducers
Author(s): Avishek Das, Manojit Pramanik ABSTRACT Light-emitting diodes (LEDs) emerge as a viable alternative to pulsed lasers in photoacoustic computed tomography (PACT) due to their low cost, compact form factor, wavelength flexibility, and reduced safety concerns. Unlike class-IV laser systems, LED-based excitation eliminates regulatory constraints while enabling high pulse-repetition rates (PRRs) and flexible modulation for […]
Clinical Pilot Study of Ionizing Radiation Acoustic Imaging for Real-Time Visualization of Radiation Therapy Dose Delivery in Cancer Patients
Author(s): K. C. Cuneo, W. Zhang, D. Litzenberg, Y. Huang, S. Hadley, I. Oraiqat, K.-W. Chang, G. Gonzalez, S. Dykstra, M. Zhang, E. G. Moros, P. L. Carson, I. El Naqa, and X. Wang ABSTRACT This study aimed to evaluate the feasibility of using ionizing radiation acoustic imaging (iRAI) to map the delivered dose in […]
In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice
Author(s): Kristie Huda, Dylan J. Lawrence, Weylan Thompson, Sarah H. Lindsey & Carolyn L. Bayer ABSTRACT Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases, and many therapies are therefore targeted to the vasculature. Therapeutics which are selective for the diseased vasculature are ideal, but whole-body selectivity of a therapeutic is challenging to assess […]
Radiomics-driven perfusion prediction in clinical photoacoustic foot imaging
Author(s): Chuqin Huang a, Yanda Cheng a, Xiaoyu Zhang b, Ye Zhan c, Wenhan Zheng a, Isabel Komornicki d, Linda M. Harris d, Wenyao Xu b, Jun Xia a ABSTRACT Accurate assessment of tissue perfusion is essential for managing chronic foot ulcers in patients with diabetes and peripheral arterial disease. While photoacoustic (PA) imaging enables high-resolution […]
Investigating the Impact of Prenatal Alcohol Exposure on Fetal Cardiac Development Using Photoacoustic Tomography
Author(s): M. F. Tanvir, H. Yang, J. D. Gardner, and H. Jiang ABSTRACT Prenatal alcohol exposure (PAE) is a leading cause of developmental abnormalities, yet its effects on fetal cardiac development remain understudied. We employed real-time, label-freemultispectral photoacoustic tomography (PAT) to noninvasively assess cardiac development in mouse fetuses exposed to chronic alcohol. Using a custom-built […]
Direct Monitoring of Whole-Brain Electrodynamics via High-Spatiotemporal-Resolution Photoacoustics with Voltage-Sensitive Dye
Author(s): W. Pang, B. Zhu, H. Li, Y. Zhou, C. M. Woo, X. Huang, T. Zhong, H. Lo, L. Wang, P. Lai, and L. Nie ABSTRACT This work proposes a novel method for monitoring deep-brain electrodynamics with a voltage-sensitive dye (VSD)-based photoacoustic imaging platform, called PA-VSD. This platform is demonstrated to allow for effectively localizing […]
Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging
Author(s): F. Ghane Golmohamadi, A. Mehmood, H. T. Phan, F.-J. Schmitt, and J. Laufer ABSTRACT Pump-probe excitation of fluorophores has been shown to overcome the limitations of conventional multiwavelength imaging and linear unmixing approaches by providing fluorophore-specific contrast whilst eliminating the dominant background signal of endogenous chromophores. In this study, methods for generating pump-probe signals and images are […]
Single Wavelength Reconstruction of Optical Absorption Coefficient and Elastic Modulus Utilizing Photoacoustic Tomography
Author(s): L. Gong, C. Cai, F. Lin, Z. Xu, Z. Wang, H. Li, and Y. Liu ABSTRACT In this study, we utilized a home-made photoacoustic tomography system to recover optical absorption coefficient and elastic modulus under single wavelength. To reconstruct the optical absorption coefficient from photoacoustic measurements, we amalgamate the finite element solutions to the […]
