Authors: Kristina Bjegovic, Leshan Sun, Prabodh Pandey, Veljko Grilj, Paola Ballesteros-Zebadua, Ryan Paisley, Gilberto Gonzalez, Siqi Wang, Marie Catherine Vozenin, Charles L Limoli and Shawn (Liangzhong) Xiang ABSTRACT Objective. The primary goal of this research is to demonstrate the feasibility of radiation-induced acoustic imaging (RAI) as a volumetric dosimetry tool for ultra-high dose rate FLASH […]
Category: Publication
TOWARD REAL-TIME, VOLUMETRIC DOSIMETRY FOR FLASH-CAPABLE CLINICAL SYNCHROCYCLOTRONS USING PROTOACOUSTIC IMAGING
Authors: Siqi Wang, Gilberto Gonzalez, Daniel Rocky Owen, Leshan Sun, Yan Liu, Townsend Zwart, Yong Chen, Liangzhong Xiang ABSTRACT BackgroundRadiation delivery with ultra-high dose rate (FLASH) radiotherapy (RT) holds promise for improving treatment outcomes and reducing side effects but poses challenges in radiation delivery accuracy due to its ultra-high dose rates. This necessitates the development […]
REAL-TIME TRACKING OF THE BRAGG PEAK DURING PROTON THERAPY VIA 3D PROTOACOUSTIC IMAGING IN A CLINICAL SCENARIO
Authors: Siqi Wang, Gilberto Gonzalez, Leshan Sun, Yifei Xu, Prabodh Pandey, Yong Chen & Shawn (Liangzhong) Xiang ABSTRACT Proton radiotherapy favored over X-ray photon therapy due to its reduced radiation exposure to surrounding healthy tissues, is highly dependent on the accurate positioning of the Bragg peak. Existing methods like PET and prompt gamma imaging to […]
Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
Author(s): Iaroslav B. Belyaev, Ivan V. Zelepukin, Polina A. Kotelnikova, Gleb V. Tikhonowski, Anton A. Popov, Alina Yu. Kapitannikova, Jugal Barman, Alexey N. Kopylov, Daniil N. Bratashov, Ekaterina S. Prikhozhdenko, Andrei V. Kabashin, Sergey M. Deyev, Andrei V. Zvyagin ABSTRACT Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical […]
The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy
Author(s): Wei Zhang, Dale Litzenberg, Yaocai Huang, Kai-Wei Chang, Ibrahim Oraiqat, Scott Hadley, Eduardo G. Moros, Man Zhang, Paul L. Carson, Kyle C. Cuneo, Issam EI Naqa, Xueding Wang ABSTRACT Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is the development of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition […]
Toward in vivo dosimetry in external beam radiotherapy using x-ray acoustic computed tomography: A soft-tissue phantom study validation
Author(s): Hao Lei, Wei Zhang, Ibrahim Oraiqat, Zhipeng Liu, Jun Ni, Xueding Wang, Issam El Naqa ABSTRACT Purpose: To study, using phantoms made from biological tissues, the feasibility and practical challenges of monitoring the position of the radiation beam and the deposited dose by x-ray acoustic computed tomography (XACT) during external beam radiotherapy delivery. Material and methods: A prototype XACT system […]
GPU-Accelerated 3D Volumetric X-Ray-Induced Acoustic Computed Tomography
Author(s): Donghyun Lee, Eun-Yeong Park, Seongwook Choi, Hyeongsub Kim, Jung-joon Min, Changho Lee, and Chulhong Kim ABSTRACT X-ray acoustic imaging is a hybrid biomedical imaging technique that can acoustically monitor X-ray absorption distribution in biological tissues through the X-ray induced acoustic effect. In this study, we developed a 3D volumetric X-ray-induced acoustic computed tomography (XACT) […]
Spatiotemporal Image Reconstruction to Enable High-Frame-Rate Dynamic Photoacoustic Tomography with Rotating-Gantry Volumetric Imagers
Author(s): Refik Mert Cam, Chao Wang, Weylan Thompson, Sergey A. Ermilov, Mark A. Anastasio, Umberto Villa ABSTRACT Dynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, current dynamic PACT imaging techniques are often limited to two-dimensional spatial imaging. Although volumetric PACT imagers are commercially available, these systems typically employ a rotating measurement gantry in […]
Water-Soluble Fe(II) Complexes for Theranostic Application: Synthesis, Photoacoustic Imaging, and Photothermal Conversion
Authors: Maeva Delcroix, Dr. Anil Reddy Marri, Stéphane Parant, Dr. Philippe C. Gros, Dr. Mathilde Bouché ABSTRACT Significant effort focused on developing photoactivatable theranostics for localized image guided therapy of cancer by thermal ablation. In this context iron complexes were recently identified as photoactivatable theranostic agents with adequate biocompatibility and body clearance. Herein, a series of FeII complexes bearing polypyridine […]
Model-Based 3-D X-Ray Induced Acoustic Computerized Tomography
Authors: Prabodh Kumar Pandey; Siqi Wang; Leshan Sun; Lei Xing; Liangzhong Xiang ABSTRACT X-ray-induced acoustic (XA) computerized tomography (XACT) is an evolving imaging technique that aims to reconstruct the X-ray energy deposition from XA measurements. Main challenges in XACT are the poor signal-to-noise ratio and limited field-of-view, which cause artifacts in the images. We demonstrate the efficacy of model-based […]
