Authors: Karl Kratkiewicz1,4,Rayyan Manwar2,4, Yang Zhou, Moein Mozaffarzadeh3, Kamran Avanaki2 ABSTRACT Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the vantage system from Verasonics for simultaneous ultrasound (US) and photoacoustic (PA) imaging. This was the motivation to write […]
Category: Publication
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]
DUAL-MODALITY X-RAY-INDUCED RADIATION ACOUSTIC AND ULTRASOUND IMAGING FOR REAL-TIME MONITORING OF RADIOTHERAPY
Authors: Wei Zhang,1 Ibrahim Oraiqat,2 Hao Lei,3 Paul L. Carson,1,4 Issam EI Naqa,2 and Xueding Wang1,4 ABSTRACT Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) […]
INDOCYANINE GREEN DYE BASED BIMODAL CONTRAST AGENT TESTED BY PHOTOACOUSTIC/FLUORESCENCE TOMOGRAPHY SETUP
Authors: MAKSIM D. MOKROUSOV1, WEYLAN THOMPSON,2 SERGEY A. ERMILOV2, TATIANA ABAKUMOVA,1, MARINA V. NOVOSELOVA,1, OLGA A. INOZEMTSEVA,3, TIMOFEI S. ZATSEPIN,1,4, VLADIMIR P. ZHAROV,5, EKATERINA I. GALANZHA,5,DMITRY A. GORIN,1,* ABSTRACT Multimodal imaging systems are in high demand for preclinical research, experimental medicine, and clinical practice. Combinations of photoacoustic technology with other modalities including fluorescence, ultrasound, MRI, OCT […]
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kima,b, Anthony M Yua, Kelsey P. Kubelicka,b, Stanislav Y. Emelianova,b ABSTRACT Matrix metalloproteinase-9 (MMP-9) plays major roles in extracellular matrix (ECM) remodeling and membrane protein cleavage, suggesting a high correlation with cancer cell invasion and tumor metastasis. Here, we present a contrast agent based on a DNA aptamer that can selectively target human […]
BREAKTHROUGH INSTRUMENTS AND PRODUCTS PHOTOSONUS M+ LASER FOR PHOTOACOUSTIC IMAGING
Authors: Aldas Juronis and Mantvydas Jašinskas ABSTRACT This report highlights PhotoSonus M+, a tunable wavelength laser system recently introduced and developed specifically for photoacoustic imaging applications, where the highest imaging depth and resolution are required. Click HERE to view publication
PHOTOACOUSTIC TOMOGRAPHY TO ASSESSACUTE VASOACTIVITY OF SYSTEMIC VASCULATURE
Author(s): Huda, Kristieª; Lawrence, Dylanª; Lindsey, Sarah; Bayer, Carolynª* ABSTRACT Vasoactivity is an important physiological indicator of cardiovascular health which is frequently measured using ex vivo vessels to determine functional mechanisms and evaluate pharmacological responses. Currently, there are no imaging methods available to assess vasoactivity in multiple vascular beds of living animals noninvasively. In this […]
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Authors: Hengrong Lana,b,c,1, Daohuai Jianga,b,c,1, Feng Gaoa, Fei Gaoa,* ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. […]
PHOTOACOUSTIC IMAGING FOR IN VIVO QUANTIFICATION OF ALCOHOL-INDUCED STRUCTURAL AND FUNCTIONAL CHANGES IN CEREBRAL VASCULATURE IN HIGH ALCOHOL-PREFERRING MICE (HAP)
Authors: Augustine Meombe Mbolle, Hao Yang, Huabei Jiang* ABSTRACT Alcohol-induced structural and functional changes were studied in vivo by photoacoustic tomography (PAT) of the cerebrovascular system in selectively bred alcohol-preferring mice. High (HAP) and low (LAP) alcohol-preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to […]
TRANSFONTANELLE PHOTOACOUSTIC IMAGING: ULTRASOUND TRANSDUCER SELECTION ANALYSIS
Authors: Rayyan Manwar,1,4,5; Tarikul Islam, MD1,6; Seyed Mohsen Ranjbaran,2,4,7; Kamran Avanaki,1,3,8 ABSTRACT Transfontanelle ultrasound imaging (TFUI) is the conventional approach for diagnosing brain injury in neonates. Despite being the first stage imaging modality, TFUI lacks accuracy in determining the injury at an early stage due to degraded sensitivity and specificity. Therefore, a modality like photoacoustic […]