Authors: Rick Van Bergen, Leshan Sun, Prabodh Kumar Pandey, Siqi Wang, Kristina Bjegovic, Gilberto Gonzalez, Yong Chen, Richard Lopata, Liangzhong Xiang ABSTRACT Radiation-induced acoustics (RIA) shows promise in advancing radiological imaging and radiotherapy dosimetry methods. However, RIA signals often require extensive averaging to achieve reasonable signal-to-noise ratios, which increases patient radiation exposure and limits real-time […]
Category: Publication
MONODISPERSE SUB-100 NM AU NANOSHELLS FOR LOW-FLUENCE DEEP-TISSUE PHOTOACOUSTIC IMAGING
Author(s): Luis D. B. Manuel, Vinion Devpaul Vincely, Carolyn Bayer, and Kevin M. McPeak ABSTRACT Nanoparticles with high absorption cross sections will advance therapeutic and bioimaging nanomedicine technologies. While Au nanoshells have shown great promise in nanomedicine, state-of-the-art synthesis methods result in scattering-dominant particles, mitigating their efficacy in absorption-based techniques that leverage the photothermal effect, […]
SIZE-TUNABLE ICG-BASED CONTRAST AGENT PLATFORM FOR TARGETED NEAR-INFRARED PHOTOACOUSTIC IMAGING
Author(s): Shrishti Singh, Giovanni Giammanco, Chih-Hsiang Hu, Joshua Bush, Leandro Soto Cordova, Dylan J Lawrence, Jeffrey L Moran, Parag V Chitnis, Remi Veneziano Fig. 6. In vivo imaging using RGD-JAAZ particles. (A) Schematic and photograph of the 3D PAI acquisition on the TriTom™ imaging system. (B) Coronal and axial slabs of the baseline PA signal acquired at 895 nm. (C) Representative coronal and […]
FUNCTIONAL PHOTOACOUSTIC IMAGING FOR PLACENTAL MONITORING: A MINI REVIEW
Author(s): Vinoin Devpaul Vincely, Carolyn L Bayer ABSTRACT The placenta, a highly vascularized interface between the mother and fetus, undergoes dramatic anatomical and functional changes during pregnancy. These changes occur both during healthy development and adverse pathologies of pregnancy, such as preeclampsia. Abnormal placental development can lead to life-long health impacts on both the mother and […]
SPHERICAL-VIEW PHOTOACOUSTIC TOMOGRAPHY FOR MONITORING IN VIVO PLACENTAL FUNCTION
Author(s): Kristie Huda , Chengxi Wu , Jaclyn G. Sider, Carolyn L. Bayer ABSTRACT Photoacoustic tomography has great potential to image dynamic functional changes in vivo. Many tomographic systems are built with a circular view geometry, necessitating a linear translation along one axis of the subject to obtain a three-dimensional volume. In this work, we evaluated a prototype […]
NON-INVASIVE 3D PHOTOACOUSTIC TOMOGRAPHY OF ANGIOGRAPHIC ANATOMY AND HEMODYNAMICS OF FATTY LIVERS IN RATS
Author(s): Xin Tong, Li Lin, Peng Hu, Rui Cao, Yang Zhang, Joshua Olick-Gibson,and Lihong V. Wang ABSTRACT Non-alcoholic fatty liver disease is the most common liver disorder worldwide, which strongly correlates to obesity, diabetes, and metabolic syndromes. Complementary to mainstream liver diagnostic modalities, photoacoustic tomography (PAT) can provide high-speed images with functional optical contrast. However, […]
WHOLE-BODY HUMAN ULTRASOUND TOMOGRAPHY
Author(s): D. C. Garrett, J. Xu, D. Oh, Y. Aborahama, G. Ku, K. Maslov, W. W. Tseng, and L. V. Wang ABSTRACT We developed a system for whole-body human ultrasound tomography in reflection andtransmission modes. A custom 512-element ultrasound receiver array with a rotating single-element ultrasound transmitter are used to generate 2D isotropically resolved images […]
A COMBINED ULTRASOUND AND PHOTOACOUSTIC IMAGING PLATFORM FOR CLINICAL RESEARCH APPLICATIONS
Author(s): Weylan Thompson, Hans-Peter Brecht, Sergey A. Ermilov, Vassili Ivanov ABSTRACT We present the continued development of a clinical ultrasound (US) imaging device with a photoacoustic (PA) mode. The combined USPA imaging platform is designed around a compact US component capable of B-mode, M-mode, color Doppler, and pulsed wave Doppler US imaging modes with a 128-element US probe. […]
HYBRID PHOTOACOUSTIC ULTRASOUND IMAGING SYSTEM FOR COLD-INDUCED VASOCONSTRICTION AND VASODILATION MONITORING
Author(s): Ruochong Zhang, Xiuting Li, Ghayathri Balasundaram, Baocheng Li, Yi Qi, Anindita Santosa, Tze Chin Tan, Malini Olivo, Renzhe Bi ABSTRACT Lewis hunting reaction refers to the alternating cold-induced vasoconstriction and dilation in extremities, whose underlying mechanism is complex. While numerous studies reported this intriguing phenomenon by measuring cutaneous temperature fluctuation under cold exposure, few of them tracked peripheral vascular responses in real-time, […]
A 3D IMAGING SYSTEM INTEGRATING PHOTOACOUSTIC AND FLUORESCENCE ORTHOGONAL PROJECTIONS FOR ANATOMICAL, FUNCTIONAL, AND MOLECULAR ASSESSMENT OF RODENT MODELS
Authors: Hans P. Brecht, Vassili Ivanov, Diego S. Dumani, Stanislav Y. Emelianov, Mark A. Anastasio, Sergey A. Ermilov ABSTRACT We have developed a preclinical 3D imaging instrument integrating photoacoustic tomography and fluorescence (PAFT) addressing known deficiencies in sensitivity and spatial resolution of the individual imaging components. PAFT is designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal projections at each […]
