Recent Posts

Disease Monitoring

PhotoSounds OEM Line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage.

PhotoSound’s ADCs are feature-rich, they have multiple electronic and optical trigger inputs as well as programmable outputs that allow the timing control of additional devices. It is possible to combine multiple ADCs in parallel. Simultaneous acquisition of 4096 channels has been realized routinely.

How does PhotoSound equipment aid with disease monitoring?

PhotoSound imaging equipment has been developed to aid in the research of disease progression, using their abilities to generate highly sensitive and high-resolution anatomical images whether due to structural changes from Alcohol Use Disorder, monitoring vasoconstriction during hypothermia, or imaging neovascular formation in cancer, including liver and heart disease.

High Alcohol Preferring Mice
Estimation and comparison of selected blood vessels between HAP mice and LAP mice. 

PhotoSound Product Used

Legion ADC

Photoacoustic imaging for in vivo quantification of alcohol-induced structural and functional changes in cerebral vasculature in high alcohol-preferring mice (HAP)

Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography

Investigating the Impact of Prenatal Alcohol Exposure on Fetal Cardiac Development Using Photoacoustic Tomography

Neuroimaging

What is Neuroimaging?

Neuroimaging is the use of medical imaging techniques to study the structure and function of the nervous system, focusing on the brain. Photoacoustic tomography has been used to image the brain, spinal cord, and other parts of the nervous system.

PhotoSound Product Used

TriTom

Monitoring Neonatal Brain Hemorrhage Progression by Photoacoustic Tomography

Photoacoustic Image-Guided Delivery of Plasmonic-Nanoparticle-Labeled Mesenchymal Stem Cells to the Spinal Cord

MoleculUS

Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring

Legion ADC

Direct Monitoring of Whole-Brain Electrodynamics via High-Spatiotemporal-Resolution Photoacoustics with Voltage-Sensitive Dye

Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Photoacoustic imaging for in vivo quantification of alcohol-induced structural and functional changes in cerebral vasculature in high alcohol-preferring mice (HAP)
Monitoring neonatal brain hemorrhage progression by photoacoustic tomography

Legion AMP

Transfontanelle photoacoustic imaging: ultrasound transducer selection analysis

Anatomical Imaging

What is anatomical imaging?

Anatomical imaging is used to visualize the structure and organization of tissues and organs within the body. Photoacoustic tomography generates high-resolution images of blood-rich tissues without the need for exogenous contrast agents.

PhotoSound Product Used

TriTom

Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot

Photoacoustic tomography to assess acute vasoactivity of systemic vasculature
Breakthrough instruments and products PhotoSonus M+ laser for photoacoustic imaging

MoleculUS

Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Legion ADC

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging

Whole-Body Human Ultrasound Tomography
Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging

Radiation-Induced Acoustic Signal Denoising using a Supervised Deep Learning Framework for Imaging and Therapy Monitoring

Y-Net: Hybrid deep learning image reconstruction for photoacoustic tomography in vivo

Deep learning enabled real-time photoacoustic tomography system via single data acquisition channel

Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats
Size-adjustable ring-shape photoacoustic tomography imager in vivo
Photoacoustic Imaging for in vivo quantification of alcohol-induced structural and functional changes in cerebral vasculature in high alcohol-preferring mice (HAP)
Real-time photoacoustic data acquisition with a thousand parallel channels at hundreds frames per second
Massive parallel ultrasound and photoacoustic PC-based system
Monitoring Neonatal Brain Hemorrhage Progression by Photoacoustic Tomography

Legion AMP

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment
Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging

Non-invasive photoacoustic computed tomography of rat heart anatomy and function

Cancer Imaging

What is Cancer Imaging?

Cancer imaging: In applications related to cancer, photoacoustic tomography has been used to noninvasively monitor tumor size, evaluate tumor metastasis, and detect the response to novel cancer therapies.

breast cancer illustration
Early detection of breast cancer matters

PhotoSound Product Used

TriTom

Water-Soluble Fe(II) Complexes for Theranostic Application: Synthesis, Photoacoustic Imaging, and Photothermal Conversion
Co-registered photoacoustic and fluorescent imaging of a switchable nanoprobe based on J-aggregates of indocyanine green
Gold nanoparticles conjugated with DNA aptamer for photoacoustic detection of human matrix metalloproteinase-9

A comparative study of plasmonic nanoparticles for targeted photothermal therapy of melanoma tumors using various irradiation modes

Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

Legion ADC

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Whole-Body Human Ultrasound Tomography
Radiation-Induced Acoustic Signal Denoising Using a Supervised Deep Learning Framework for Imaging and Therapy Monitoring

Y-Net: Hybrid Deep Learning Image Reconstruction for Photoacoustic Tomography In Vivo

Deep Learning Enabled Real-Time Photoacoustic Tomography System Via Single Data Acquisition Channel

Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats

Size-Adjustable Ring-Shape Photoacoustic Tomography Imager In Vivo

Massive Parallel Ultrasound and Photoacoustic PC-Based System

Legion AMP

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Real-Time, Volumetric Imaging of Radiation Dose Delivery Deep into the Liver During Cancer Treatment
Automatic Force-Controlled 3D Photoacoustic System for Human Peripheral Vascular Imaging

Advancing precision photothermal therapy byintegrating armored gold nanostars with real-timephotoacoustic thermometry and imaging

Contrast Agent Development

What is Contrast Agent Development?

Photoacoustic contrast agents, such as indocyanine green (ICG), are used to enhance the visibility of specific targets within a subject and targeting to investigate specific molecular markers.

contrast agent development
Samples of Tubes with Dyes used as Contrast Agents

PhotoSound Product Used

TriTom

In situ x-ray-induced acoustic computed tomography with a contrast agent: a proof of concept

Biodegradable and biocompatible semiconductor nanocrystals as NIR-II photoacoustic imaging contrast agents

Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging

Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup

Water-Soluble Fe(II) Complexes for Theranostic Application: Synthesis, Photoacoustic Imaging, and Photothermal Conversion
Co-registered photoacoustic and fluorescent imaging of a switchable nanoprobe based on J-aggregates of indocyanine green
Gold nanoparticles conjugated with DNA aptamer for photoacoustic detection of human matrix metalloproteinase-9

Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

A comparative study of plasmonic nanoparticles for targeted photothermal therapy of melanoma tumors using various irradiation modes

Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging

Legion AMP

Monodisperse Sub-100 nm Au Nanoshells for Low-Fluence Deep-Tissue Photoacoustic Imaging

Transfontanelle photoacoustic imaging: ultrasound transducer selection analysis

Application Note

Contract Agent Development Application Note

Developmental Biology

What is Developmental Biology?

Photoacoustic tomography can be used to visualize and monitor the early stages of embryonic development and detect abnormalities that can affect maternal and fetal outcomes.

petri dish
Microbiology, Discovery and Exploration

PhotoSound Product Used

TriTom

Functional photoacoustic imaging for placental monitoring: A mini review

Legion ADC

Monitoring neonatal brain hemorrhage progression by photoacoustic tomography

Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography

Investigating the Impact of Prenatal Alcohol
Exposure on Fetal Cardiac Development Using
Photoacoustic Tomography

Therapeutic Monitoring

PhotoSounds OEM Line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage.

PhotoSound’s ADCs are feature-rich, they have multiple electronic and optical trigger inputs as well as programmable outputs that allow the timing control of additional devices. It is possible to combine multiple ADCs in parallel. Simultaneous acquisition of 4096 channels has been realized routinely.

What is Therapeutic Monitoring?

Noninvasive imaging plays a critical role in the development of novel drugs by enabling safe, real-time evaluation of the systemic effects of therapeutic intervention in preclinical disease models.

therapy monitoring
These before and after images are from a mouse that had been administered a therapeutic agent that causes vasodilation. The change in blood vessel diameter over time is a metric of therapeutic response.

PhotoSound Product Used

TriTom

Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies

MoleculUS

Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring

Legion ADC

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging

Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging

Radiation-induced Acoustic Signal Denoising using a Supervised Deep Learning Framework for Imaging and Therapy Monitoring

Legion AMP

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

Advancing precision photothermal therapy byintegrating armored gold nanostars with real-timephotoacoustic thermometry and imaging

Flash Amp

Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography

Molecular Imaging

What is Molecular Imaging?

Molecular imaging enables the visualization, characterization, and quantification of biological processes that take place at the cellular and subcellular levels.

Molecular Imaging
Cellular and Molecular Imaging

PhotoSound Product Used

TriTom

Commercial Small Animal Imaging Could Aid Disease Detection

Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup

A preclinical small animal imaging platform combining multi-angle photoacoustic and fluorescence projections into co-registered 3D maps

Spherical-view photoacoustic tomography for monitoring in vivo placental function

Preclinical Small Animal Imaging Platform Providing Co-registered 3D Maps of Photoacoustic Response and Fluorescence

A 3D imaging system integrating photoacoustic and fluorescence orthogonal projections for anatomical, functional and molecular assessment of rodent models

Probing the photophysical properties of fluorescent proteins using photoacoustic pump-probe spectroscopy and imaging

MoleculUS

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Legion AMP

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

REAL-TIME PHOTOACOUSTIC DATA ACQUISITION WITH A THOUSAND PARALLEL CHANNELS AT HUNDREDS FRAMES PER SECOND

Authors: Vassili Ivanov, Hans Peter Brecht, Sergey A. Ermilov

AFFILIATIONS

PhotoSound Technologies, Inc. (United States)

ABSTRACT

Large number of simultaneously acquired spatially distinct pressure signals is required to improve quality of real-time photoacoustic and x-ray acoustic biomedical images [1]. In the past this approach was limited by availability of commercial multi-channel analog-to-digital converter (ADC) systems and ability to operate multiple ADC boards with synchronized clock and trigger source. The new Legion series single-board 256-channel ADC (ADC256) was designed by PhotoSound for massive parallel data acquisition utilized in photoacoustic, laser-induced ultrasound, and X-ray acoustic real-time imaging applications. ADC256 is a 12-bit ADC with a sampling rate up to 40 MHz and a USB3 computer interface. It can run at 200 Hz frame rate with 4096 points per trigger acquired by each channel. Higher trigger rates without data loss are possible with smaller number of points per trigger. ADC256 has an integrated amplifier with programmable gain up to 51 dB. Additionally, it can be equipped with a matching photoacoustic preamplifier. The system architecture is scalable to 1024 channels using four synchronized boards with a single trigger source. The clock and the trigger can be delivered from the master ADC256 board (daisy chain) or from the clock and trigger server (star topology). The data collected by each ADC board has trigger and board stamps allowing to (a) use multiple computers for data acquisition, and (b) detection of lost data events, even if the trigger rate exceeds its maximum allowed value.

Click HERE to view publication

CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN

Authors: Diego S. Dumani, Hans-Peter Brecht, Vassili Ivanov, Ryan Deschner, Justin T. Harris, Kimberly A. Homan, Jason R. Cook, Stanislav Y. Emelianov, Sergey A. Ermilov

ABSTRACT

We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal projections at each rotational position of a biological object, enabling direct co-registration of the two imaging modalities. The nanoprobe was based on liposomes loaded with J-aggregates of indocyanine green (PAtrace). Once PAtrace interacts with the environment, a transition from J-aggregate to monomeric ICG is induced. The subsequent recovery of monomeric ICG is characterized by dramatic changes in the optical absorption spectrum and reinstated fluorescence. In the activated state, PAtrace can be simultaneously detected by both imaging modes of the PAFT instrument using 780 nm excitation and fluorescence detection at 810 nm. The fluorescence imaging component is used to boost detection sensitivity by providing low resolution map of activated nanoprobes, which are then more precisely mapped in 3D by the photoacoustic imaging component. Activated vs non-activated particles can be distinguished based on their different optical absorption peaks, removing the requirements for complex image registration between reference and detection scans. Preliminary phantom and in vivo animal imaging results showed successful activation and visualization of PAtrace with high sensitivity and resolution. The proposed PAFT-PAtrace imaging platform could be used in various functional and molecular imaging applications including multi-point in vivo assessment of early metastasis.

Click HERE to view publication