Author(s): Md Farhan Tanvir, Hao Yang, Jason D. Gardner, Huabei Jiang ABSTRACT Prenatal alcohol exposure (PAE) is a leading cause of developmental abnormalities, yet its effects on fetal cardiac development remain understudied. We employed real-time, label-freemultispectral photoacoustic tomography (PAT) to noninvasively assess cardiac development in mouse fetuses exposed to chronic alcohol. Using a custom-built PAT system, […]
Tag: photoacoustic tomography
Single Wavelength Reconstruction of Optical Absorption Coefficient and Elastic Modulus Utilizing Photoacoustic Tomography
Author(s): Gong, Linghui and Cai, Chao and Lin, Fukang and Xu, Zequan and Wang, Zhaoyu and Li, Hui and Liu, Yubin ABSTRACT In this study, we utilized a home-made photoacoustic tomography system to recover optical absorption coefficient and elastic modulus under single wavelength. To reconstruct the optical absorption coefficient from photoacoustic measurements, we amalgamate the finite […]
3D Frequency-Domain Full Waveform Inversion for Whole-Breast Imaging With a Multi-Row Ring Array
Author(s): Rehman Ali, Gaofei Jin, Melanie Singh, Trevor Mitcham, Nebojsa Duric ABSTRACT For ring-array ultrasound tomography, two-dimensional frequency-domain full waveform inversion is the clinical gold standard for high-resolution imaging of the breast. While yielding high-resolution images in the plane of the ring-array, the resulting slice-wise approach yields lower resolution out of plane when used to reconstruct […]
Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting
Author(s): Chuqin Huang, Emily Zheng, Wenhan Zheng, Huijuan Zhang, Yanda Cheng, Xiaoyu Zhang, Varun Shijo, Robert W. Bing, Isabel Komornicki, Linda M. Harris, Ermelinda Bonaccio, Kazuaki Takabe, Emma Zhang, Wenyao Xu, Jun Xia ABSTRACT Photoacoustic tomography (PAT) is an emerging imaging modality with widespread applications in both preclinical and clinical studies. Despite its promising capabilities to provide high-resolution images, the […]
Utility of Low-Cost Multichannel Data Acquisition System for Photoacoustic Computed Tomography
Author(s): Zafar, Mohsin, Rayyan Manwar, Seyed Mohsen Ranjbaran, and Kamran Avanaki ABSTRACT Typically, multi-single-element photoacoustic computed tomography (PACT) systems utilize numerous ultrasound transducers arranged in cylindrical or hemispherical configurations for detection, combined with a single diffuse light source or multiple sparse light sources to illuminate the imaging target. While these systems produce high-quality 3D PA images, […]
Signal-domain speed-of-sound correction for ring-array-based photoacoustic tomography
Author(s): Daohuai Jiang, Hengrong Lan, Shangqing Tong, Xianzeng Zhang, Fei Gao ABSTRACT Photoacoustic imaging combines the advantages of optical and acoustic imaging, making it a promising tool in biomedical imaging. Photoacoustic tomography (PAT) reconstructs images by solving the inverse problem from detected photoacoustic waves to initial pressure map. The heterogeneous speed of sound (SoS) distribution in biological tissue significantly affects […]
Contrast Agent Development Application Note
TriTomTM Contrast Agent Develpoment The development of novel optical imaging contrast agents requires extensive testing in both phantoms and animal models to ensure the safety and utility of the agent for in vivo applications. However, evaluating the biodistribution and clearance of a contrast agent remains challenging in preclinical studies due to limited whole-body real-time imaging […]
Anatomical Imaging Application Note
TriTom™ Photoacoustic Imaging Platform: Small Animal Anatomical Imaging The ability to directly visualize and evaluate anatomical structures and biological processes in small animal models at the whole-body level is critical for understanding the pathophysiology of human diseases. The TriTom™ small animal imaging platform provides noninvasive high-resolution photoacoustic tomography (PAT) images that can be used to extract functional and […]
Brain Imaging Application Note
Photoacoustic Neuroimaging with the TriTomTM Brain imaging, or neuroimaging, is used to understand the relationship between brain function and behavior and study the underlying causes of neurological and psychiatric diseases. It is important in helping to understand the relationship between specific areas of the brain and what function they serve. Photoacoustic Imaging (PAI) relies on differential […]
Cancer Imaging Application Note
Cancer Detection and Monitoring with the TriTomTM Photoacoustic imaging has become a popular tool in preclinical cancer research as a noninvasive technique for monitoring tumor growth and therapeutic response. Specifically, photoacoustic imaging can provide high-sensitivity images of both superficial and deep vasculature and quantitative assessment of blood oxygen saturation without exogenous contrast. The TriTom small […]