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SCIENTIFIC PRESENTATIONS USING PHOTOSOUND PRODUCTS AT SPIE 2024

We look forward to seeing you at one of the scientific presentations using PhotoSound Technologies, Inc. products during SPIE Photonics West 2024. See the list of presentations below.

12842-15

The new development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

Author(s): Wei Zhang, Dale Litzenberg, Yaocai Huang, Scott Hadley, Kai-Wei Chang, Univ. of Michigan Medical School (United States); Ibrahim Oraiqat, Eduardo Moros, Moffitt Cancer Ctr. (United States); Man Zhang, Paul Carson, Kyle Cuneo, Univ. of Michigan Medical School (United States); Issam EI Naqa, Moffitt Cancer Ctr. (United States); Xueding Wang, Univ. of Michigan Medical School (United States)

28 January 2024 • 1:45 PM – 2:00 PM PST | Moscone Center, Room 54 (Lower Mezzanine South)

12842-16

Whole-body ultrasound and thermoacoustic tomography for human imaging, needle localization, and ablation monitoring

Author(s): David C. Garrett, Jinhua Xu, Geng Ku, Lihong V. Wang, Caltech (United States)

28 January 2024 • 2:00 PM – 2:15 PM PST | Moscone Center, Room 54 (Lower Mezzanine South)

12842-17

Rotational photoacoustic and ultrasound tomography of the human body

Author(s): Yang Zhang, Shuai Na, Jonathan J. Russin, Li Lin, Yilin Luo, Yujin An, Peng Hu, Karteekeya Sastry, Konstantin Maslov, Charles Y. Liu, Lihong V. Wang Caltech (United States)

28 January 2024 • 2:15 PM – 2:30 PM PST | Moscone Center, Room 54 (Lower Mezzanine South)

12842-93

Rational design of ICG-based contrast agents for near-infrared photoacoustic imaging

Author(s): Marzieh Hanafi, Nicholas Such, Giovanni Giammanco, Shrishti Singh, George Mason Univ. (United States); Dana Wegierak, Eric Abenojar, Pinunta Nittayacharn, Tessa Kosmides, Agata A. Exner, Case Western Reserve Univ. (United States); Remi Veneziano, Parag V. Chitnis, George Mason Univ. (United States)

28 January 2024 • 5:30 PM – 7:00 PM PST | Moscone Center, Room 2003 (Level 2 West)

12842-50

Combined ionizing radiation acoustic and ultrasound dual-modality volumetric imaging for mapping the dose on anatomical structure during radiation therapy

Author(s): Wei Zhang, Univ. of Michigan Medical School (United States); Ibrahim Oraiqat, Moffitt Cancer Ctr. (United States); Yaocai Huang, Kaiwei Chang, Univ. of Michigan Medical School (United States); Muhammad B. Alli, Moffitt Cancer Ctr. (United States); Dale Litzenberg, Scott Hadley, Univ. of Michigan Medical School (United States); Christopher Tichacek, Eduardo Moros, Moffitt Cancer Ctr. (United States); Man Zhang, Paul Carson, Kyle Cuneo, Univ. of Michigan Medical School (United States); Issam EI Naqa, Moffitt Cancer Ctr. (United States); Xueding Wang, Univ. of Michigan Medical School (United States)

29 January 2024 • 4:30 PM – 4:45 PM PST | Moscone Center, Room 54 (Lower Mezzanine South)

12842-51

High-throughput photoacoustic tomography by integrated robotics and automation

Author(s): Nathanael Marshall, Hans-Peter Brecht, Weylan Thompson, Dylan Lawrence, Vanessa Marshall, PhotoSound Technologies, Inc. (United States); Mark A. Anastasio, Univ. of Illinois (United States); Umberto Villa, The Univ. of Texas at Austin (United States); Sergey Ermilov, PhotoSound Technologies, Inc. (United States)

29 January 2024 • 4:45 PM – 5:00 PM PST | Moscone Center, Room 54 (Lower Mezzanine South)

12842-125

A fast fully automated dual-SOS reconstruction algorithm for full-ring array PACT

Author(s): Shunyao Zhang, Lei S. Li, Rice Univ. (United States)

29 January 2024 • 5:30 PM – 7:00 PM PST | Moscone Center, Room 2003 (Level 2 West)

12842-131

Optoacoustic imaging of coronary arteries for bypass surgery using a handheld lens-free probe

Author(s): Zohar Or, Technion-Israel Institute of Technology (Israel); Itay Or, Mahli Raad, Gil Bolotin, Rambam Medical Ctr. (Israel); Amir Rosenthal, Technion-Israel Institute of Technology (Israel)

30 January 2024 • 6:00 PM – 8:00 PM PST | Moscone Center, Room 2003 (Level 2 West)

#SPIEPhotonicsWest #BiOSExpo #2024 #photosoundtechnologies #photosound #photoacoustic #fluorescence #imaging #biomedicalscience #biomedicalresearch #science #tomography #productdemonstration #livedemonstration

SPIE Photonics West 2024

PhotoSound Technologies is excited to attend this year’s SPIE Photonics West BiOS -the industry’s most important biophotonics, biomedical optics, and imaging meeting being held in San Francisco, CA January 27 – February 1, 2024.  Come talk to us and see our products in person at this year’s BIOS Exhibition at Photonics West in San Francisco on January 27-28 2024. We will be at booth 8539.

We are excited to announce that PhotoSound Technologies Inc. has been selected as a finalist for the 2024 SPIE Prism Award for our revolutionary new product MoleculUS in the Biomedical category!

The SPIE Prism Awards recognize the best new photonics products and technologies on the market. We are honored to be among the finalists alongside such innovative companies. The SPIE Prism Awards will be presented during a gala at Photonics West on January 31, 2024. We are grateful to SPIE for recognizing our work, and we look forward to competing in the finals at Photonics West in January.

Congratulations to all of the finalists!

#photoacoustic #SPIE #photonicswest #BIOS #research

Model-Based 3-D X-Ray Induced Acoustic Computerized Tomography

Authors: Prabodh Kumar Pandey; Siqi Wang; Leshan Sun; Lei Xing; Liangzhong Xiang

ABSTRACT

X-ray-induced acoustic (XA) computerized tomography (XACT) is an evolving imaging technique that aims to reconstruct the X-ray energy deposition from XA measurements. Main challenges in XACT are the poor signal-to-noise ratio and limited field-of-view, which cause artifacts in the images. We demonstrate the efficacy of model-based (MB) algorithms for 3-D XACT and compare with the traditional algorithms. The MB algorithms are based on the matrix free approach for regularized-least-squares minimization corresponding to XACT. The matrix-free-LSQR (MF-LSQR) and the noniterative model-backprojection (MBP) reconstructions were evaluated and compared with universal backprojection (UBP), time-reversal (TR), and fast-Fourier transform (FFT)-based reconstructions for numerical and experimental XACT datasets. The results demonstrate the capability of the MF-LSQR algorithm to reduce noisy artifacts thus yielding better reconstructions. MBP and MF-LSQR algorithms perform particularly well with the experimental XACT dataset, where noise in signals significantly affects the reconstruction of the target in UBP and FFT-based reconstructions. The TR reconstruction for experimental XACT is comparable to MF-LSQR, but takes thrice as much time and filters the frequency components greater than maximum frequency supported by the grid, resulting loss of resolution. The MB algorithms are able to overcome the challenges in XACT and hence are vital for the clinical translation of XACT.

Click HERE to view publication

Discrete Wavelet Transformation for the Sensitive Detection of Ultrashort Radiation Pulse with Radiation-Induced Acoustics

Authors: Rick Van Bergen, Leshan Sun, Prabodh Kumar Pandey, Siqi Wang, Kristina Bjegovic, Gilberto Gonzalez, Yong Chen, Richard Lopata, Liangzhong Xiang

ABSTRACT

Radiation-induced acoustics (RIA) shows promise in advancing radiological imaging and radiotherapy dosimetry methods. However, RIA signals often require extensive averaging to achieve reasonable signal-to-noise ratios, which increases patient radiation exposure and limits real-time applications. Therefore, this article proposes a discrete wavelet transform (DWT)-based filtering approach to denoise the RIA signals and avoid extensive averaging. The algorithm was benchmarked against low-pass filters and tested on various types of RIA sources, including low-energy X-rays, high-energy X-rays, and protons. The proposed method significantly reduced the required averages (1000 times less averaging for low-energy X-ray RIA, 32 times less averaging for high-energy X-ray RIA, and four times less averaging for proton RIA) and demonstrated robustness in filtering signals from different sources of radiation. The coif5 wavelet in conjunction with the sqtwolog threshold selection algorithm yielded the best results. The proposed DWT filtering method enables high-quality, automated, and robust filtering of RIA signals, with a performance similar to low-pass filtering, aiding in the clinical translation of radiation-based acoustic imaging for radiology and radiation oncology.

Click HERE for publication

Radiation Acoustics

PhotoSounds OEM line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage.

PhotoSound’s ADCs are feature-rich, they have multiple electronic and optical trigger inputs as well as programmable outputs that allow the timing control of additional devices. It is possible to combine multiple ADCs in parallel. Simultaneous acquisition of 4096 channels has been realized routinely.

What is Radiation Acoustics?

Radiation Acoustics is the conversion of pulsed energy in form of electrons, protons X-rays and microwaves into sound waves. For example the interaction of X-rays and tissue is weaker than that of optical light which allows for deep penetration. However, the same weak interaction is greatly reducing contrast. The long pulse duration of X-ray sources limits the spatial resolution of X-ray acoustic imaging systems.

While probably unable to compete as an imaging technique in comparison to conventional imaging solutions, it offers unique possibilities for monitoring and dosimetry of radiation therapy. Accurate real-time monitoring of dosage and placement can potentially be a game changer in radiation therapy and would reduce the amount of treatment cycles and time required.

Photosound products are uniquely suited for the acquisition of acoustic signals generated by pulsed X-rays. The high input impedance of our preamplifier ensures the faithful recording of low-frequency signals, their high gain, and low SNR along with the high channel count minimizes the amount of X-ray pulses required to require data.

PhotoSound Product Used

Legion AMP

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

Toward in vivo dosimetry in external beam radiotherapy using x-ray acoustic computed tomography: A soft-tissue phantom study validation

The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

Legion ADC

4D in vivo dosimetry for a FLASH electron beam using radiation-induced acoustic imaging

Discrete Wavelet Transformation for the Sensitive Detection of Ultrashort Radiation Pulse with Radiation-Induced Acoustics

Model-Based 3-D X-Ray Induced Acoustic Computerized Tomography

Real-time tracking of the Bragg peak during proton therapy via 3D protoacoustic Imaging in a clinical scenario

Toward real-time, volumetric dosimetry for FLASH-capable clinical synchrocyclotrons using protoacoustic imaging

TriTom

GPU-Accelerated 3D Volumetric X-Ray-Induced Acoustic Computed Tomography

In Situ X-Ray Induced Acoustic Computed Tomography with a Contrast Agent: A Proof of Concept

MONODISPERSE SUB-100 NM AU NANOSHELLS FOR LOW-FLUENCE DEEP-TISSUE PHOTOACOUSTIC IMAGING

August 4, 2023

Author(s): Luis D. B. Manuel, Vinion Devpaul Vincely, Carolyn Bayer, and Kevin M. McPeak

ABSTRACT

Nanoparticles with high absorption cross sections will advance therapeutic and bioimaging nanomedicine technologies. While Au nanoshells have shown great promise in nanomedicine, state-of-the-art synthesis methods result in scattering-dominant particles, mitigating their efficacy in absorption-based techniques that leverage the photothermal effect, such as photoacoustic (PA) imaging. We introduce a highly reproducible synthesis route to monodisperse sub-100 nm Au nanoshells with an absorption-dominant optical response. Au nanoshells with 48 nm SiO2 cores and 7 nm Au shells show a 14-fold increase in their volumetric absorption coefficient compared to commercial Au nanoshells with dimensions commonly used in nanomedicine. PA imaging with Au nanoshell contrast agents showed a 50% improvement in imaging depth for sub-100 nm Au nanoshells compared with the smallest commercially available nanoshells in a turbid phantom. Furthermore, the high PA signal at low fluences, enabled by sub-100 nm nanoshells, will aid the deployment of low-cost, low-fluence light-emitting diodes for PA imaging.

Click HERE to view publication

SIZE-TUNABLE ICG-BASED CONTRAST AGENT PLATFORM FOR TARGETED NEAR-INFRARED PHOTOACOUSTIC IMAGING

2022 Dec 11

Author(s): Shrishti Singh, Giovanni Giammanco, Chih-Hsiang Hu, Joshua Bush, Leandro Soto Cordova, Dylan J Lawrence, Jeffrey L Moran, Parag V Chitnis, Remi Veneziano

ABSTRACT

Near-infrared photoacoustic imaging (NIR-PAI) combines the advantages of optical and ultrasound imaging to provide anatomical and functional information of tissues with high resolution. Although NIR-PAI is promising, its widespread use is hindered by the limited availability of NIR contrast agents. J-aggregates (JA) made of indocyanine green dye (ICG) represents an attractive class of biocompatible contrast agents for PAI. Here, we present a facile synthesis method that combines ICG and ICG-azide dyes for producing contrast agents with tunable size down to 230 nm and direct functionalization with targeting moieties. The ICG-JA platform has a detectable PA signal in vitro that is two times stronger than whole blood and high photostability. The targeting ability of ICG-JA was measured in vitro using HeLa cells. The ICG-JA platform was then injected into mice and in vivo NIR-PAI showed enhanced visualization of liver and spleen for 90 min post-injection with a contrast-to-noise ratio of 2.42.

Click HERE to view publication

FUNCTIONAL PHOTOACOUSTIC IMAGING FOR PLACENTAL MONITORING: A MINI REVIEW

available on 2024-09-29

Author(s): Vinoin Devpaul Vincely, Carolyn L Bayer

ABSTRACT

The placenta, a highly vascularized interface between the mother and fetus, undergoes dramatic anatomical and functional changes during pregnancy. These changes occur both during healthy development and adverse pathologies of pregnancy, such as preeclampsia. Abnormal placental development can lead to life-long health impacts on both the mother and child. Photoacoustic (PA) imaging, extensively developed for preclinical imaging applications in oncology and cardiovascular disease, uses optical energy to generate acoustic waves through thermoelastic expansion of light-absorbing chromophores within tissue. Recently, photoacoustic imaging has been used to study preclinical placental anatomy and function. If clinical translation of photoacoustic imaging of the placenta is achieved, the impact on maternal-fetal health could be expansive. This perspective highlights the recent progress in photoacoustic imaging for placental monitoring and discusses the progress needed for human clinical translation.

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SPHERICAL-VIEW PHOTOACOUSTIC TOMOGRAPHY FOR MONITORING IN VIVO PLACENTAL FUNCTION

29 September 2020

Author(s): Kristie Huda , Chengxi Wu , Jaclyn G. Sider, Carolyn L. Bayer

ABSTRACT

Photoacoustic tomography has great potential to image dynamic functional changes in vivo. Many tomographic systems are built with a circular view geometry, necessitating a linear translation along one axis of the subject to obtain a three-dimensional volume. In this work, we evaluated a prototype spherical view photoacoustic tomographic system which acquires a 3D volume in a single scan, without linear translation. We simultaneously measured relative hemoglobin oxygen saturation in multiple placentas of pregnant mice under oxygen challenge. We also synthesized a folate-conjugated indocyanine green (ICG) contrast agent to image folate kinetics in the placenta. Photoacoustic tomography performed at the wavelength of peak optical absorption of our contrast agent revealed increased ICG signal over time. Through these phantom and in vivo studies, we have demonstrated that the spherical view 3D photoacoustic tomographic system achieves high sensitivity and fast image acquisition, enabling in vivo experiments to assess physiological and molecular dynamics.

Click HERE to view publication